Laboratory of Research in Bacteriology; Faculdade de Medicina; Universidade Federal de Minas Gerais; Belo Horizonte, Brazil.
Leeds Institute Molecular Medicine; St. James's University Hospital; University of Leeds; Leeds, UK.
Gut Microbes. 2013 Nov-Dec;4(6):494-504. doi: 10.4161/gmic.26277. Epub 2013 Aug 28.
Helicobacter pylori infection is predominantly acquired early in life. The prevalence of the infection in childhood is low in developed countries, whereas in developing countries most children are infected by 10 y of age. In poor resource settings, where malnutrition, parasitic/enteropathogen and H. pylori infection co-exist in young children, H. pylori might have potentially more diverse clinical outcomes. This paper reviews the impact of childhood H. pylori infection in developing countries that should now be the urgent focus of future research. The extra-gastric manifestations in early H. pylori infection in infants in poor resource settings might be a consequence of the infection associated initial hypochlorhydria. The potential role of H. pylori infection on iron deficiency, growth impairment, diarrheal disease, malabsorption and cognitive function is discussed in this review.
幽门螺杆菌感染主要在生命早期获得。在发达国家，儿童时期的感染率较低，而在发展中国家，大多数儿童在 10 岁之前就已感染。在资源匮乏的环境中，营养不良、寄生虫/肠道病原体和幽门螺杆菌感染在幼儿中同时存在，幽门螺杆菌可能具有更多不同的临床结果。本文综述了发展中国家儿童幽门螺杆菌感染的影响，这应该成为未来研究的紧迫重点。在资源匮乏环境中，婴儿早期幽门螺杆菌感染的胃外表现可能是感染相关初始低胃酸的结果。本文还讨论了幽门螺杆菌感染对缺铁、生长障碍、腹泻病、吸收不良和认知功能的潜在作用。
