Chilla R, Haubrich J
Laryngol Rhinol Otol (Stuttg). 1976 Oct;55(10):816-23.
Penicillin levels were determined in both serum and tonsillar tissue 1-2 h (29 patients) and 3-4 h (16 patients) after intramuscular application of Penicillin-G resp. oral doses of Penicillin-V. All tonsils were found to contain different amounts of Penicillin. Concentrations of antibiotic in the tonsillar tissues are dependent on the respective serum levels. The serum-tonsil-difference of the Penicillin levels increases significantly in adults. The efficiency of oral and intramuscular Penicillin application and the occasionally described failure of oral Penicillin medication are discussed with regard to the minimal inhibitory concentrations (MIC) for group A streptococci.
在肌肉注射青霉素G或口服青霉素V后1 - 2小时（29例患者）和3 - 4小时（16例患者），分别测定血清和扁桃体组织中的青霉素水平。发现所有扁桃体均含有不同量的青霉素。扁桃体组织中抗生素的浓度取决于各自的血清水平。青霉素水平的血清 - 扁桃体差异在成年人中显著增加。针对A组链球菌的最低抑菌浓度（MIC），讨论了口服和肌肉注射青霉素的疗效以及偶尔描述的口服青霉素治疗失败的情况。
