Scaglione F, Falchi M, Ferrara F, Signorelli S, Aimini R, D'Orsi S, Pintucci G P, Fraschini F
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Int J Clin Pharmacol Res. 1990;10(5):265-70.
The kinetic profile in tonsils of cefonicid has been studied in 30 patients who underwent tonsillectomy after administration of a single intramuscular dose of 1 g. Blood and tissue samples were withdrawn 1, 2, 3, 6, 12 and 24 h after administration of the drug. The analytical determination was performed employing a microbiological method. Peak serum levels appeared at the first hour (94.2 +/- 9.83 mg/l), while peak tissue values were determined in samples collected at the third hour (11.9 +/- 3.68 mg/kg). Serum levels at the 24th hour were 3.82 +/- 1.25 mg/l. Levels in the tonsils were 7.54 +/- 2.96 mg/kg at the sixth hour, 3.34 +/- 1.42 mg/kg at the twelfth hour and 0.40 +/- 0.31 mg/kg at the 24th hour.
对30例单次肌内注射1克头孢尼西后接受扁桃体切除术的患者，研究了头孢尼西在扁桃体中的动力学特征。给药后1、2、3、6、12和24小时采集血液和组织样本。采用微生物学方法进行分析测定。血清峰值水平出现在第1小时（94.2±9.83毫克/升），而组织峰值在第3小时采集的样本中测定（11.9±3.68毫克/千克）。第24小时的血清水平为3.82±1.25毫克/升。扁桃体中的水平在第6小时为7.54±2.96毫克/千克，第12小时为3.34±1.42毫克/千克，第24小时为0.40±0.31毫克/千克。
