突触蛋白可预测阿尔茨海默病和路易体痴呆的认知能力下降。
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
机构信息
Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
King's College London, Wolfson Centre for Age-Related Diseases, London, UK.
出版信息
Alzheimers Dement. 2016 Nov;12(11):1149-1158. doi: 10.1016/j.jalz.2016.04.005. Epub 2016 May 22.
INTRODUCTION
Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia.
METHODS
A total of 129 postmortem human brain samples were analyzed in brain regional specific manner exploring their associations with morphologic changes and cognitive decline.
RESULTS
We have observed robust changes reflecting synaptic dysfunction in all studied dementia groups. There were significant associations between the rate of cognitive decline and decreased levels of Rab3 in DLB in the inferior parietal lobe and SNAP25 in AD in the prefrontal cortex. Of particular note, synaptic proteins significantly discriminated between dementia cases and controls with over 90% sensitivity and specificity.
DISCUSSION
Our findings suggest that the proposition that synaptic markers can predict cognitive decline in AD, should be extended to Lewy body diseases.
简介
我们的目的是比较三种参与突触传递不同步骤的突触蛋白的水平：Rab3A、SNAP25 和神经颗粒蛋白，这三种蛋白存在于三种常见的痴呆症中：阿尔茨海默病（AD）、路易体痴呆（DLB）和帕金森病痴呆。
方法
共分析了 129 个人类大脑尸检样本，以大脑区域特异性的方式探索它们与形态变化和认知能力下降的关系。
结果
我们观察到所有研究的痴呆症组都存在反映突触功能障碍的明显变化。在顶叶下小叶的 DLB 和前额叶的 AD 中，Rab3 的水平下降与认知能力下降的速度之间存在显著关联，SNAP25 与认知能力下降的速度之间存在显著关联。值得注意的是，突触蛋白可以区分痴呆症患者和对照组，具有超过 90%的敏感性和特异性。
讨论
我们的发现表明，突触标志物可以预测 AD 认知能力下降的观点，应该扩展到路易体疾病。
Zotero 插件