Wimberly Alexandra S, Ivey Megan, Rennert Lior, McKay James R
School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
AIDS Behav. 2017 Apr;21(4):1082-1090. doi: 10.1007/s10461-016-1434-6.
Evaluate the effect of continuing care interventions for cocaine use with HIV risk-reduction components on HIV sex-risk. Explore whether cocaine use at treatment initiation interacts with the type of continuing care intervention to affect HIV sex-risk. Cocaine dependent participants (N = 321) were randomized to: (1) Treatment as usual (TAU): intensive outpatient treatment, (2) TAU and telephone monitoring and counseling (TMC), and (3) TAU and TMC plus incentives for participation in telephone contacts (TMC+). Participants in TMC and TMC+ received a brief HIV intervention, with booster sessions as needed. Generalized estimating equations analysis compared TAU, TMC and TMC+ at 6, 12, 18, 24 months post-baseline on the following outcomes: overall HIV sex-risk, number of sexual partners, condom usage, exchange of drugs for sex, exchange of sex for drugs, exchange of money for sex, exchange of sex for money, and crack house visits. Overall sex-risk decreased for all treatment conditions at follow-up, with no treatment main effects. For people with no cocaine use at baseline, TAU experienced greater sex-risk reductions than TMC (p < .01) and TMC+ (p < .001). The three treatment conditions are effective in reducing HIV sex-risk. TMC with HIV risk-reduction components is unnecessary for cocaine-dependent clients who stop using cocaine early in treatment.
评估包含降低HIV风险成分的可卡因使用持续护理干预措施对HIV性风险的影响。探究治疗开始时的可卡因使用情况是否与持续护理干预类型相互作用以影响HIV性风险。321名可卡因依赖参与者被随机分为:(1)常规治疗(TAU):强化门诊治疗;(2)TAU加电话监测与咨询(TMC);(3)TAU加TMC并对参与电话联系给予激励(TMC+)。TMC和TMC+组的参与者接受了简短的HIV干预,并根据需要进行强化辅导。广义估计方程分析在基线后6、12、18、24个月比较了TAU、TMC和TMC+在以下结果方面的情况:总体HIV性风险、性伴侣数量、避孕套使用情况、以性换毒品、以毒品换性、以钱换性、以性换钱以及光顾毒品窝点的情况。随访时所有治疗组的总体性风险均降低,不存在治疗的主效应。对于基线时不使用可卡因的人,TAU组的性风险降低幅度大于TMC组(p <.01)和TMC+组(p <.001)。三种治疗条件均能有效降低HIV性风险。对于在治疗早期就停止使用可卡因的可卡因依赖患者,包含降低HIV风险成分的TMC是不必要的。