Ishibashi Jeff, Seale Patrick
Institute for Diabetes, Obesity , & Metabolism; Department of Cell and Developmental Biology ; Department of Genetics; Perelman School of Medicine ; University of Pennsylvania ; Philadelphia, PA USA.
Temperature (Austin). 2015 Mar 17;2(1):65-72. doi: 10.4161/23328940.2014.974444. eCollection 2015 Jan-Mar.
The PR-domain containing 16 (Prdm16) protein is a powerful inducer of the thermogenic phenotype in fat cells. In both developmental (brown) and induced (beige) thermogenic adipose tissue, Prdm16 has a critical role in maintaining proper tissue structure and function. It has roles throughout the course of differentiation, beginning with lineage determination activity in precursor cells, and continuing with coactivator functions that enable and maintain thermogenic gene expression. These abilities are primarily mediated by interactions with other adipogenic factors, suggesting that Prdm16 acts to coordinate the overall brown adipose phenotype. Mouse models have confirmed that thermogenic adipose depends upon Prdm16, and that this type of fat tissue provides substantial metabolic protection against the harmful effects of a high fat/high energy diet. Activation of Prdm16, therefore, holds promise for stimulating thermogenesis in fat cells to reduce human obesity and its complications.
含PR结构域16（Prdm16）蛋白是脂肪细胞产热表型的强力诱导剂。在发育性（棕色）和诱导性（米色）产热脂肪组织中，Prdm16在维持适当的组织结构和功能方面都起着关键作用。它在整个分化过程中都发挥作用，从在祖细胞中的谱系决定活性开始，持续到能够启动和维持产热基因表达的共激活因子功能。这些能力主要通过与其他脂肪生成因子的相互作用来介导，这表明Prdm16起到协调整体棕色脂肪表型的作用。小鼠模型已证实产热脂肪依赖于Prdm16，并且这种类型的脂肪组织为抵抗高脂/高能量饮食的有害影响提供了实质性的代谢保护。因此，激活Prdm16有望刺激脂肪细胞产热，以减轻人类肥胖及其并发症。
