Zeng Wei-Fang, Li Yan, Sheng Chang-Sheng, Huang Qi-Fang, Kang Yuan-Yuan, Zhang Lu, Wang Shuai, Cheng Yi-Bang, Li Fei-Ka, Wang Ji-Guang
Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
PLoS One. 2016 May 26;11(5):e0156041. doi: 10.1371/journal.pone.0156041. eCollection 2016.
To investigate the relationship between adiposity measures and plasma concentration of high molecular weight (HMW) adiponectin.
In a Chinese sample (n = 1081), we performed measurements of anthropometry and bioelectrical impedance analysis (BIA). We defined overweight and obesity as a body mass index between 24 and 27.4 kg/m² and ≥ 27.5 kg/m², respectively, and central obesity as a waist circumference ≥ 90 cm in men and ≥ 80 cm in women. Plasma HMW adiponectin concentration was measured by the ELISA method.
Plasma HMW adiponectin concentration was significantly (P < 0.0001) higher in women (n = 677, 2.47 μg/mL) than men (n = 404, 1.58 μg/mL) and correlated with advancing age in men (r = 0.28) and women (r = 0.29). In adjusted analyses, it was lower in the presence of overweight (n = 159, 1.26 μg/mL in men and n = 227, 2.15μg/mL in women) and obesity (n = 60, 1.31 μg/mL and n = 82, 2.10 μg/mL, respectively) than normal weight subjects (n = 185, 2.07μg/mL and n = 368, 2.94 μg/mL, respectively) and in the presence of central obesity (n = 106, 1.28 μg/mL and n = 331, 2.12 μg/mL, respectively) than subjects with a normal waist circumference (n = 298, 1.74 μg/mL and n = 346, 2.74 μg/mL, respectively). In multiple regression analyses stratified for gender, adjusted for confounders and considered separately each of the adiposity measures, all adiposity measures were significantly (r -0.18 to -0.31, P < 0.001) associated with plasma HMW adiponectin concentration. However, in further stratified and adjusted regression analyses considered stepwise all adiposity measures, only waist-to-hip ratio was significantly (P < 0.05) associated with plasma HMW adiponectin concentration in men (r = -0.10) and women (r = -0.15).
Anthropometric measures of obesity, such as waist-to-hip ratio, but not BIA measures, are independently associated with plasma adiponectin concentration.
研究肥胖指标与高分子量（HMW）脂联素血浆浓度之间的关系。
在中国样本（n = 1081）中，我们进行了人体测量和生物电阻抗分析（BIA）。我们将超重和肥胖分别定义为体重指数在24至27.4kg/m²之间和≥27.5kg/m²，将中心性肥胖定义为男性腰围≥90cm，女性腰围≥80cm。采用酶联免疫吸附测定（ELISA）法测量血浆HMW脂联素浓度。
女性（n = 677，2.47μg/mL）的血浆HMW脂联素浓度显著高于男性（n = 404，1.58μg/mL）（P < 0.0001），且与男性（r = 0.28）和女性（r = 0.29）的年龄增长相关。在调整分析中，超重者（男性n = 159，1.26μg/mL；女性n = 227，2.15μg/mL）和肥胖者（分别为男性n = 60，1.31μg/mL；女性n = 82，2.10μg/mL）的血浆HMW脂联素浓度低于正常体重者（分别为男性n = 185，2.07μg/mL；女性n = 368，2.94μg/mL），中心性肥胖者（分别为男性n = 106，1.28μg/mL；女性n = 331，2.12μg/mL）的血浆HMW脂联素浓度低于腰围正常者（分别为男性n = 298，1.74μg/mL；女性n = 346，2.74μg/mL）。在按性别分层、调整混杂因素并分别考虑每个肥胖指标的多元回归分析中，所有肥胖指标均与血浆HMW脂联素浓度显著相关（r = -0.18至-0.31，P < 0.001）。然而，在进一步逐步考虑所有肥胖指标的分层和调整回归分析中，只有腰臀比与男性（r = -0.10）和女性（r = -0.15）的血浆HMW脂联素浓度显著相关（P < 0.05）。
肥胖的人体测量指标，如腰臀比，而非BIA指标，与血浆脂联素浓度独立相关。
