Miklowitz David J, Portnoff Larissa C, Armstrong Casey C, Keenan-Miller Danielle, Breen Elizabeth C, Muscatell Keely A, Eisenberger Naomi I, Irwin Michael R
Semel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA.
Semel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA.
Psychiatry Res. 2016 Jul 30;241:315-22. doi: 10.1016/j.psychres.2016.04.120. Epub 2016 May 7.
Adults with bipolar disorder (BD) and major depressive disorder (MDD) have higher circulating levels of proinflammatory cytokines than healthy controls. However, it is not known whether pediatric-onset patients with BD or MDD show increases in levels of inflammation or activation of nuclear factor kappa B (NF-κB), a key transcription factor in inflammatory signaling. Circulating levels of inflammatory cytokines, as well as spontaneous and stimulated levels of activated NF-κB in total peripheral blood mononuclear cells, monocytes and lymphocytes were measured in adolescents with BD (n=18), MDD (n=13), or no psychiatric history (n=20). Participants had a range of mood symptoms at time of testing. Adolescents with BD had significantly higher spontaneous levels of NF-κB in peripheral blood mononuclear cells, monocyte and lymphocyte populations, and higher plasma levels of IL-1β than healthy controls. Following stimulation with recombinant human TNF-α, participants with BD and MDD both had greater increases in NF-κB in monocytes than controls. Further, greater stimulated increases of NF-κB in monocytes were associated with the current severity of depressive symptoms. The results are limited by the small sample and cross-sectional design. Interventions that target early immunological dysregulation should be examined in relation to long-term outcomes in youth with bipolar and depressive disorders.
Early Intervention for Youth at Risk for Bipolar Disorder, https://clinicaltrials.gov/ct2/show/NCT01483391.
患有双相情感障碍（BD）和重度抑郁症（MDD）的成年人循环中的促炎细胞因子水平高于健康对照者。然而，尚不清楚患有BD或MDD的儿童期发病患者是否表现出炎症水平升高或核因子κB（NF-κB）的激活，NF-κB是炎症信号传导中的关键转录因子。对患有BD（n = 18）、MDD（n = 13）或无精神病史（n = 20）的青少年测量了炎症细胞因子的循环水平，以及外周血单个核细胞、单核细胞和淋巴细胞中NF-κB的自发激活水平和刺激激活水平。参与者在测试时具有一系列情绪症状。与健康对照者相比，患有BD的青少年外周血单个核细胞、单核细胞和淋巴细胞群体中NF-κB的自发激活水平显著更高，且血浆IL-1β水平更高。在用重组人TNF-α刺激后，患有BD和MDD的参与者单核细胞中NF-κB的增加均大于对照者。此外，单核细胞中NF-κB刺激后更大的增加与当前抑郁症状的严重程度相关。结果受样本量小和横断面设计的限制。应研究针对早期免疫失调的干预措施与双相情感障碍和抑郁症青少年长期预后的关系。
双相情感障碍风险青少年的早期干预，https://clinicaltrials.gov/ct2/show/NCT01483391 。
