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国际综合医疗环境下的转诊类型、透析起始情况及肾脏替代治疗方式的选择

Type of Referral, Dialysis Start and Choice of Renal Replacement Therapy Modality in an International Integrated Care Setting.

作者信息

Marrón Belén, Ostrowski Janusz, Török Marietta, Timofte Delia, Orosz Attila, Kosicki Andrzej, Całka Alicja, Moro Daniela, Kosa Dezider, Redl Jenö, Qureshi Abdul Rashid, Divino-Filho Jose Carolino

机构信息

Diaverum Home Therapies, Medical Office, Munich, Germany.

Wloclawek Diaverum Clinic, Wloclawek, Poland.

出版信息

PLoS One. 2016 May 26;11(5):e0155987. doi: 10.1371/journal.pone.0155987. eCollection 2016.

Abstract

INTRODUCTION

Integrated Care Settings (ICS) provide a holistic approach to the transition from chronic kidney disease into renal replacement therapy (RRT), offering at least both types of dialysis.

OBJECTIVES

To analyze which factors determine type of referral, modality provision and dialysis start on final RRT in ICS clinics.

METHODS

Retrospective analysis of 626 patients starting dialysis in 25 ICS clinics in Poland, Hungary and Romania during 2012. Scheduled initiation of dialysis with a permanent access was considered as planned RRT start.

RESULTS

Modality information (80% of patients) and renal education (87%) were more frequent (p<0.001) in Planned (P) than in Non-Planned (NP) start. Median time from information to dialysis start was 2 months. 89% of patients started on hemodialysis, 49% were referred late to ICS (<3 months from referral to RRT) and 58% were NP start. Late referral, non-vascular renal etiology, worse clinical status, shorter time from information to RRT and less peritoneal dialysis (PD) were associated with NP start (p<0.05). In multivariate logistic regression analysis, P start (p≤0.05) was associated with early referral, eGFR >8.2 ml/min, >2 months between information and RRT initiation and with vascular etiology after adjustment for age and gender. "Optimal care," defined as ICS follow-up >12 months plus modality information and P start, occurred in 23%.

CONCLUSIONS

Despite the high rate of late referrals, information and education were widely provided. However, NP start was high and related to late referral and may explain the low frequency of PD.

摘要

引言

综合护理机构(ICS)为慢性肾病过渡到肾脏替代治疗(RRT)提供了一种整体方法,至少提供两种透析方式。

目的

分析在ICS诊所中,哪些因素决定了最终接受RRT时的转诊类型、透析方式的提供以及透析开始情况。

方法

对2012年波兰、匈牙利和罗马尼亚25家ICS诊所开始透析的626例患者进行回顾性分析。将计划通过永久性通路开始透析视为计划内RRT开始。

结果

与非计划(NP)开始相比,计划(P)开始时的透析方式信息(80%的患者)和肾脏教育(87%)更为常见(p<0.001)。从获取信息到开始透析的中位时间为2个月。89%的患者开始接受血液透析,49%的患者转诊至ICS较晚(从转诊到RRT<3个月),58%的患者为NP开始。转诊较晚、非血管性肾脏病因、临床状况较差、从获取信息到RRT的时间较短以及腹膜透析(PD)较少与NP开始相关(p<0.05)。在多因素逻辑回归分析中,经年龄和性别调整后,P开始(p≤0.05)与早期转诊、估算肾小球滤过率(eGFR)>8.2 ml/min、获取信息与RRT开始之间间隔>2个月以及血管性病因相关。“最佳护理”定义为ICS随访>12个月加上透析方式信息和P开始,发生率为23%。

结论

尽管转诊较晚的比例较高,但信息和教育得到了广泛提供。然而,NP开始的比例较高,且与转诊较晚相关,这可能解释了PD的低发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/4882011/e3f3a1769dab/pone.0155987.g001.jpg

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