Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794-8111, USA.
Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794-8111, USA.
Clin Chest Med. 2016 Jun;37(2):289-98. doi: 10.1016/j.ccm.2016.01.014. Epub 2016 Mar 11.
Cardiac function and dysfunction are important in the clinical outcomes of sepsis and septic shock. Cardiac dysfunction is not a single entity, but is a broad spectrum of syndromes that result in biventricular cardiac dysfunction manifested by both systolic and diastolic dysfunction and is influenced by cardiac loading conditions (ie, preload and afterload). Elucidating the underlying pathophysiology has proved to be complex. This article emphasizes the underlying pathophysiology of cardiac dysfunction and explores recent evidence related to diagnosis, including the utility of biomarkers, the role of echocardiography, and management goals and treatment.
心脏功能和功能障碍在脓毒症和感染性休克的临床结局中很重要。心脏功能障碍不是单一实体，而是广泛的综合征，导致双心室心脏功能障碍，表现为收缩和舒张功能障碍，并受心脏负荷条件（即前负荷和后负荷）的影响。阐明潜在的病理生理学一直被证明是复杂的。本文强调了心脏功能障碍的潜在病理生理学，并探讨了与诊断相关的最新证据，包括生物标志物的效用、超声心动图的作用以及管理目标和治疗。
