Rupp Bernhard, Wlodawer Alexander, Minor Wladek, Helliwell John R, Jaskolski Mariusz
k.-k. Hofkristallamt, Vista, CA, USA.
Department of Genetic Epidemiology, Medical University of Innsbruck, Austria.
FEBS J. 2016 Dec;283(24):4452-4457. doi: 10.1111/febs.13765. Epub 2016 Jun 10.
Seriously flawed and even fictional models of biomolecular crystal structures, although rare, still persist in the record of structural repositories and databases. The ensuing problems of database contamination and persistence of publications based on incorrect structure models must be effectively addressed. The burden cannot be simply left to the critical voices who take the effort to contribute dissenting comments that are mostly ignored. The entire structural biology community, and particularly the journal editors who exercise significant power in this respect, must engage in a constructive dialog lest structural biology lose its credibility as an evidence-based empirical science.
严重有缺陷甚至虚构的生物分子晶体结构模型,尽管罕见,但仍存在于结构储存库和数据库的记录中。基于不正确结构模型的数据库污染以及相关出版物持续存在的问题必须得到有效解决。不能仅仅将负担留给那些努力发表不同意见却大多被忽视的批评声音。整个结构生物学界,尤其是在这方面拥有重大权力的期刊编辑,必须进行建设性对话,以免结构生物学失去作为一门基于证据的实证科学的可信度。