食物对两种茶碱控释颗粒生物利用度的影响。

Influence of food on bioavailability from two controlled-release granules of theophylline.

作者信息

Tada H, Ishikawa M, Sato E, Suzuki T, Unno K, Miura K, Ohmiya Y, Nakai K

机构信息

Department of Pharmaceutical Science, Akita University Hospital, Japan.

出版信息

J Clin Pharm Ther. 1989 Apr;14(2):145-51. doi: 10.1111/j.1365-2710.1989.tb00233.x.

DOI:10.1111/j.1365-2710.1989.tb00233.x

PMID:2722977

Abstract

The bioavailability and absorption pattern of theophylline from Theolong granule and Theodur-G were studied in five healthy volunteers both in fasting conditions and after taking two different meals. In all the subjects, no dose-dumping effect was observed with a standard- or a fat-rich breakfast on these preparations. Postprandial administration delayed the absorption of theophylline and a fat-rich breakfast significantly reduced the area under the curve (AUC0-26) for both preparations. The mean AUC decreased by 14.0% for the former and 19.7% for the latter when the fat-rich breakfast was administered. Intake of a standard breakfast resulted in a decrease in the AUC0-26 by 10.6% for Theolong granules but there was little effect observed with the Theodur-G granules.

摘要

在五名健康志愿者中，研究了茶氨酸在空腹条件下以及在食用两种不同餐食后，从Theolong颗粒剂和氨茶碱控释片（Theodur-G）中的生物利用度和吸收模式。在所有受试者中，标准早餐或高脂早餐对这些制剂均未观察到剂量倾泻效应。餐后给药延迟了茶氨酸的吸收，高脂早餐显著降低了两种制剂的曲线下面积（AUC0-26）。给予高脂早餐时，前者的平均AUC降低了14.0%，后者降低了19.7%。摄入标准早餐使Theolong颗粒剂的AUC0-26降低了10.6%，但氨茶碱控释片（Theodur-G）颗粒剂几乎未观察到影响。