PGC1α 抑制前列腺癌的进展。
PGC1α drives a metabolic block on prostate cancer progression.
机构信息
Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
出版信息
Nat Cell Biol. 2016 May 27;18(6):589-90. doi: 10.1038/ncb3365.
DOI:10.1038/ncb3365
PMID:27230528
Abstract
Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.
摘要
代谢重编程对癌细胞的存活至关重要。PGC1α 是一种在前列腺癌中下调的转录共激活因子，它通过激活一种防止肿瘤生长和转移扩散的氧化代谢程序来控制前列腺癌的代谢。
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