自闭症从学前到学龄期：3岁诊断后8年的神经精神问题
Preschool to School in Autism: Neuropsychiatric Problems 8 Years After Diagnosis at 3 Years of Age.
作者信息
Barnevik Olsson M, Lundström S, Westerlund J, Giacobini M B, Gillberg C, Fernell E
机构信息
Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
PRIMA Child and Adult Psychiatry, Götgatan 71, 116 21, Stockholm, Sweden.
出版信息
J Autism Dev Disord. 2016 Aug;46(8):2749-2755. doi: 10.1007/s10803-016-2819-0.
The study presents neuropsychiatric profiles of children aged 11 with autism spectrum disorder, assessed before 4.5 years, and after interventions. The original group comprised a community sample of 208 children with ASD. Parents of 128 participated-34 with average intellectual function, 36 with borderline intellectual function and 58 with intellectual disability. They were interviewed using the Autism-Tics, AD/HD and other Comorbidities interview. Criteria for a clinical/subclinical proxy of ASD were met by 71, 89 and 95 %, respectively. Criteria for at least one of ASD, AD/HD, Learning disorder or Developmental Coordination Disorder were met by 82, 94 and 97 %. More than 90 % of children with a preschool diagnosis of ASD have remaining neuropsychiatric problems at 11, despite early intervention.
该研究呈现了11岁自闭症谱系障碍儿童在4.5岁之前及干预后的神经精神状况。最初的样本包括来自社区的208名患有自闭症谱系障碍的儿童。128名儿童的家长参与了研究，其中34名儿童智力功能正常，36名儿童智力功能处于临界状态，58名儿童存在智力残疾。研究人员使用《自闭症-抽动症、注意力缺陷多动障碍及其他共病访谈》对家长进行了访谈。分别有71%、89%和95%的儿童符合自闭症谱系障碍临床/亚临床替代标准。分别有82%、94%和97%的儿童符合自闭症谱系障碍、注意力缺陷多动障碍、学习障碍或发育协调障碍中至少一项的标准。尽管进行了早期干预，但超过90%在学龄前被诊断为自闭症谱系障碍的儿童在11岁时仍存在神经精神问题。
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