Frediani Jamie N, Fabbri Muller
Children's Center for Cancer and Blood Diseases and The Saban Research Institute, Children's Hospital, Los Angeles, Los Angeles, CA, USA.
Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mol Cancer. 2016 May 26;15(1):42. doi: 10.1186/s12943-016-0525-3.
MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review focuses on the state-of-the-art knowledge of the role of miRNAs in the complexity of the TME and highlights limitations and challenges in the field. A better understanding of the mechanisms of action of these fascinating micro molecules will lead to the development of new therapeutic weapons and most importantly, to an improvement in the clinical outcome of cancer patients.
微小RNA（miRNA）正逐渐成为塑造肿瘤微环境（TME）生物学特性的核心因素。它们通过调节TME中不同细胞内的表达水平，以及通过在外泌体和其他细胞外囊泡中在不同细胞群体之间穿梭来实现这一点。本综述聚焦于miRNA在TME复杂性中作用的最新知识，并强调了该领域的局限性和挑战。更好地理解这些迷人的微小分子的作用机制将带来新治疗手段的发展，最重要的是，改善癌症患者的临床结局。
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