自噬、炎性小体与线粒体之间的联系
The Connections Among Autophagy, Inflammasome and Mitochondria.
作者信息
de Lavera Isabel, Pavon Ana Delgado, Paz Marina Villanueva, Oropesa-Avila Manuel, de la Mata Mario, Alcocer-Gomez Elizabet, Garrido-Maraver Juan, Cotan David, Alvarez-Cordoba Monica, Sanchez-Alcazar Jose A
机构信息
Centro Andaluz de Biologia, del Desarrollo [CABD]. Universidad Pablo de Olavide-Consejo Superior de Investigaciones Cientificas. Carretera de Utrera Km 1, Sevilla 41013, Spain.
出版信息
Curr Drug Targets. 2017;18(9):1030-1038. doi: 10.2174/1389450117666160527143143.
BACKGROUND
The molecular crosstalk between inflammation and autophagy is an emerging field of research that is essential for the understanding of multicellular organism homeostasis and how these processes influence a variety of pathological conditions.
OBJECTIVE
In this review, we briefly describe the relationship between autophagy and inflammasome activation. The central role that mitochondria play in both cellular processes is also discussed.
CONCLUSION
Inflammasome and autophagy often modulate each other by common inhibitory mechanisms that are controlled by different input pathways. Thus, inflammasome components coordinate autophagy and autophagy regulates inflammasome activation, making the balance between both processes a fundamental player in cellular homeostasis.
背景
炎症与自噬之间的分子相互作用是一个新兴的研究领域，对于理解多细胞生物体内稳态以及这些过程如何影响多种病理状况至关重要。
目的
在本综述中，我们简要描述自噬与炎性小体激活之间的关系。还讨论了线粒体在这两个细胞过程中所起的核心作用。
结论
炎性小体和自噬通常通过由不同输入途径控制的共同抑制机制相互调节。因此，炎性小体成分协调自噬，而自噬调节炎性小体激活，使得这两个过程之间的平衡成为细胞内稳态的一个基本因素。
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