Fujii T, Takamizawa M, Kawana T, Juji T, Mizuno M
Department of Obstetrics and Gynecology, Tokyo University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Feb;41(2):115-21.
Thirty-two primary habitual aborters who had more than 3 abortions during the early stages of pregnancies without any known causes of habitual abortions were studied. The degree of HLA-DR compatibility of the patient couples was similar to that of 70 control couples. The patients were treated with intra-dermal injections of their husbands' lymphocytes 4 times every 2 weeks. The skin reactions at the sites of the injection were estimated 24 hours and 48 hours after the first and fourth injections. The mixed lymphocyte reaction (MLR) after the last injection decreased in the patients whose skin reaction was weaker following the last injection than the first (p = 0.007), and these patients had a good prognosis for subsequent pregnancies (p = 0.010). On the other hand, the MLR after the last injection did not weaken in the patients whose skin reaction did not become weaker (p = 0.007), and in these patients abortion resulted in subsequent pregnancies (p = 0.010). The HLA-DR compatibility of the patient couple and anti-HLA-DR antibody induced by the treatment did not affect the prognosis for subsequent pregnancies.
对32名原发性习惯性流产患者进行了研究，这些患者在妊娠早期有3次以上流产，且无任何已知的习惯性流产原因。患者夫妇的HLA-DR相容性程度与70对对照夫妇相似。患者每2周接受4次皮内注射其丈夫的淋巴细胞治疗。在第一次和第四次注射后24小时和48小时评估注射部位的皮肤反应。最后一次注射后，皮肤反应比第一次注射后减弱的患者，其混合淋巴细胞反应（MLR）降低（p = 0.007），这些患者随后妊娠的预后良好（p = 0.010）。另一方面，皮肤反应未减弱的患者最后一次注射后的MLR没有减弱（p = 0.007），在这些患者中，随后妊娠会导致流产（p = 0.010）。患者夫妇的HLA-DR相容性以及治疗诱导产生的抗HLA-DR抗体并不影响随后妊娠的预后。
