Cauchi M N, Koh S H, Tait B, Mraz G, Kloss M, Pepperell R J
Aust N Z J Obstet Gynaecol. 1987 Feb;27(1):52-4. doi: 10.1111/j.1479-828x.1987.tb00934.x.
Recent evidence suggests that immunological factors could play a role in the aetiology of habitual abortion. In this study, 71 couples with habitual abortion (i.e. more than 3 successive abortions) were investigated. Sharing of HLA-A, B, DR between partners was not found to be significantly increased. Anti-HLA antibodies in women against their partners' lymphocytes were found in 18.3%. After immunization with 10(7)-10(8) lymphocytes obtained from husband or unrelated donor, there was a seroconversion rate of 61% in those without antibodies initially. This was not dependent on the number of cells injected, source of cells, degree of sharing of HLA antigens or whether the couple were primary aborters (i.e. having had no advanced pregnancy), or secondary aborters. Seven pregnancies have resulted following the immunization procedure so far, 5 occurring in cross-match positive patients and 2 in cross-match negative. Growth retarded infants resulted from the pregnancy of 1 primary aborter and 2 secondary aborters.
最近的证据表明，免疫因素可能在习惯性流产的病因中起作用。在本研究中，对71对习惯性流产夫妇（即连续3次以上流产）进行了调查。未发现伴侣之间HLA-A、B、DR的共享显著增加。18.3%的女性体内发现了针对伴侣淋巴细胞的抗HLA抗体。在用从丈夫或无关供体获得的10⁷-10⁸淋巴细胞进行免疫后，最初没有抗体的人血清转化率为61%。这与注射的细胞数量、细胞来源、HLA抗原的共享程度或这对夫妇是原发性流产者（即没有过晚期妊娠）还是继发性流产者无关。到目前为止，免疫程序后已有7例妊娠，其中5例发生在交叉配型阳性患者中，2例发生在交叉配型阴性患者中。1例原发性流产者和2例继发性流产者的妊娠导致了胎儿生长受限。
