Kobayashi H
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Feb;41(2):143-8.
The possibility of the endometrial production of CA125 and the effect of P4, MPA, and E2 were investigated using tissue cultures of eutopic endometrium (uterine endometrium obtained from uterine myoma) and heterotopic endometrium (uterine myometrium obtained from adenomyosis). CA125 was detected in eutopic endometrium before culture, its concentration being significantly higher in tissues obtained during the early proliferative phases than in those obtained during the early secretion. On the other hand, no significant changes in the tissue concentrations of CA125 before culture were found in heterotopic endometrium during a menstrual cycle. In the heterotopic endometrium, in the production of CA125 in the medium was higher than that in the eutopic one. The data on CA125 in the culture medium also indicated that the production was significantly higher during the proliferative phases than during secretion. Cycloheximide significantly decreased the concentrations of CA125 in the medium and in tissues of the eutopic and heterotopic endometrium. The production of CA125 was not affected by the addition of P4, but MPA significantly inhibited the in-vitro production of CA125, which could no longer be observed when E2 was simultaneously added to the medium. These results indicated that not only the eutopic but also the heterotopic endometrium could produce CA125, and this ability seems to be more marked in the heterotopic than that in the eutopic endometrium, especially during the secretory phases. This study demonstrated one of the causes of increased serum CA125 in patients with adenomyosis.
利用在位内膜（从子宫肌瘤中获取的子宫内膜）和异位内膜（从子宫腺肌病中获取的子宫肌层）的组织培养，研究了子宫内膜产生CA125的可能性以及孕酮（P4）、甲羟孕酮（MPA）和雌二醇（E2）的作用。培养前在位内膜中可检测到CA125，其浓度在增殖早期获取的组织中显著高于分泌早期获取的组织。另一方面，异位内膜在月经周期中培养前组织中的CA125浓度无显著变化。在异位内膜中，培养基中CA125的产生高于在位内膜。培养基中CA125的数据还表明，增殖期的产生显著高于分泌期。放线菌酮显著降低了在位和异位内膜培养基及组织中CA125的浓度。P4的添加不影响CA125的产生，但MPA显著抑制CA125的体外产生，当同时向培养基中添加E2时则不再观察到这种抑制作用。这些结果表明，不仅在位内膜而且异位内膜都能产生CA125，并且这种能力在异位内膜中似乎比在位内膜更明显，尤其是在分泌期。本研究揭示了子宫腺肌病患者血清CA125升高的原因之一。
