[pH对小肠上皮细胞间连接通透性和力学性能的影响]
[Effect of pH on the permeability and mechanical properties of intercellular contacts in the small intestinal epithelium].
作者信息
Melikiants A G, Batoev V B
出版信息
Biofizika. 1978 May-Jun;23(3):485-8.
PMID:27238
Abstract
It is shown that acid site population controlling ion permeation through cell contacts is localized in the region of tight junction. The isoelectric point of cell surface in the region to tight junction changed from mean pH = 2.37 +/- 0.1 for duodenum to pH =2.80 +/- +/- 0.1 for ileum. The maximum of cell adhesion in the tissue reached at mean pH that corresponding the isoelectric point. It seems possible, that this acid site population take part in interaction of plasma membranes of neighbouring cells.
摘要
结果表明，控制离子通过细胞连接渗透的酸性位点群体位于紧密连接区域。紧密连接区域的细胞表面等电点从十二指肠的平均pH = 2.37±0.1变为回肠的pH = 2.80±0.1。组织中的细胞黏附最大值出现在与等电点对应的平均pH值处。这种酸性位点群体似乎有可能参与相邻细胞质膜的相互作用。
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