Hansen Malene, Kennedy Brian K
Sanford Burnham Prebys Medical Research Institute, La Jolla, CA 92037, USA.
Buck Institute for Research on Aging, Novato, CA 94945, USA.
Trends Cell Biol. 2016 Aug;26(8):565-568. doi: 10.1016/j.tcb.2016.05.002. Epub 2016 May 27.
Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to lifespan extension also improving healthspan?
曾经被认为是不可能的事情,现在很明显,改变几个保守的基因途径的活性可以延长实验生物体的寿命。然而,对于人类来说,目标是延长健康寿命,即生命中功能正常且无疾病的时期。目前延长寿命的途径是否也能改善健康寿命呢?