Zhang Meng, Wei Jin, Sun Yu, He Chang, Ma Shiyin, Pan Xudong, Zhu Xiaoyan
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
J Adv Res. 2025 Mar;69:31-49. doi: 10.1016/j.jare.2024.03.008. Epub 2024 Mar 17.
Aging is characterized by an ongoing struggle between the buildup of damage caused by a combination of external and internal factors. Aging has different effects on phagocytes, including impaired efferocytosis. A deficiency in efferocytosis can cause chronic inflammation, aging, and several other clinical disorders.
Our review underscores the possible feasibility and extensive scope of employing dual targets in various age-related diseases to reduce the occurrence and progression of age-related diseases, ultimately fostering healthy aging and increasing lifespan. Key scientific concepts of review Hence, the concurrent implementation of strategies aimed at augmenting efferocytic mechanisms and anti-aging treatments has the potential to serve as a potent intervention for extending the duration of a healthy lifespan. In this review, we comprehensively discuss the concept and physiological effects of efferocytosis. Subsequently, we investigated the association between efferocytosis and the hallmarks of aging. Finally, we discuss growing evidence regarding therapeutic interventions for age-related disorders, focusing on the physiological processes of aging and efferocytosis.
衰老的特征是由外部和内部因素共同作用导致的损伤不断积累。衰老对吞噬细胞有不同影响，包括吞噬作用受损。吞噬作用缺陷可导致慢性炎症、衰老及其他几种临床病症。
我们的综述强调了在各种与年龄相关的疾病中采用双重靶点以减少与年龄相关疾病的发生和进展的可能可行性和广泛范围，最终促进健康衰老并延长寿命。综述的关键科学概念 因此，同时实施旨在增强吞噬机制的策略和抗衰老治疗有可能成为延长健康寿命的有力干预措施。在本综述中，我们全面讨论了吞噬作用的概念和生理效应。随后，我们研究了吞噬作用与衰老特征之间的关联。最后，我们讨论了关于与年龄相关疾病的治疗干预的越来越多的证据，重点关注衰老和吞噬作用的生理过程。
