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本文引用的文献

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Liver Transpl. 2016 May;22(5):644-55. doi: 10.1002/lt.24393. Epub 2016 Apr 5.
2
Histologically proven non-alcoholic fatty liver disease and clinically related factors in recipients after liver transplantation.肝移植受者中经组织学证实的非酒精性脂肪性肝病及临床相关因素
Clin Transplant. 2014 May;28(5):521-9. doi: 10.1111/ctr.12343. Epub 2014 Apr 16.
3
Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment.非酒精性脂肪性肝病/肝炎：流行病学、发病机制、临床表现和治疗。
Dig Dis. 2012;30(2):158-62. doi: 10.1159/000336669. Epub 2012 Jun 20.
4
Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review.肝移植后同种异体 C282Y 纯合子供肝发生肝铁过载：病例报告及文献复习。
Liver Int. 2011 Nov;31(10):1589-92. doi: 10.1111/j.1478-3231.2011.02606.x. Epub 2011 Jul 29.
5
Split liver transplantation: an overview.劈离式肝移植：概述
Transplant Proc. 2011 Apr;43(3):884-7. doi: 10.1016/j.transproceed.2011.02.036.
6
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.利用超声和肝活检对以中老年人为主的人群进行非酒精性脂肪性肝病和非酒精性脂肪性肝炎的患病率：一项前瞻性研究。
Gastroenterology. 2011 Jan;140(1):124-31. doi: 10.1053/j.gastro.2010.09.038. Epub 2010 Sep 19.
7
Liver transplantation for inherited metabolic disorders of the liver.肝移植治疗肝脏遗传性代谢疾病。
Curr Opin Organ Transplant. 2010 Jun;15(3):269-76. doi: 10.1097/MOT.0b013e3283399dbd.
8
Non-alcoholic fatty liver disease in liver transplant recipients: another story of "seed and soil".肝移植受者的非酒精性脂肪性肝病：“种子与土壤”的又一故事。
Am J Gastroenterol. 2010 Mar;105(3):613-20. doi: 10.1038/ajg.2009.717. Epub 2009 Dec 29.
9
De novo nonalcoholic fatty liver disease after liver transplantation.肝移植后新发非酒精性脂肪性肝病
Liver Transpl. 2007 Jun;13(6):844-7. doi: 10.1002/lt.20932.
10
Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma.拓展非酒精性脂肪性肝炎的自然史：从隐源性肝硬化到肝细胞癌。
Gastroenterology. 2002 Jul;123(1):134-40. doi: 10.1053/gast.2002.34168.

宿主因素在肝移植后非酒精性脂肪性肝炎的发生中起主导作用。

Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis.

作者信息

Boga Salih, Munoz-Abraham Armando Salim, Rodriguez-Davalos Manuel I, Emre Sukru H, Jain Dhanpat, Schilsky Michael L

机构信息

Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.

出版信息

World J Hepatol. 2016 May 28;8(15):659-64. doi: 10.4254/wjh.v8.i15.659.

DOI:10.4254/wjh.v8.i15.659
PMID:27239259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4876289/
Abstract

Non-alcoholic fatty liver disease (NAFLD) is a recognized problem in patients after orthotopic liver transplantation and may lead to recurrent graft injury. As the increased demand for liver allografts fail to match the available supply of donor organs, split liver transplantation (SLT) has emerged as an important technique to increase the supply of liver grafts. SLT allows two transplants to occur from one donor organ, and provides a unique model for observing the pathogenesis of NAFLD with respect to the role of recipient environmental and genetic factors. Here we report on two recipients of a SLT from the same deceased donor where only one developed non-alcoholic steatohepatitis (NASH), suggesting that host factors are critical for the development of NASH.

摘要

非酒精性脂肪性肝病（NAFLD）是原位肝移植术后患者中一个公认的问题，可能导致移植肝反复损伤。由于对肝移植的需求增加但供体器官供应不足，活体肝移植（SLT）已成为增加肝移植供体数量的一项重要技术。SLT可使一个供体器官用于两台移植手术，并为观察受体环境和遗传因素在NAFLD发病机制中的作用提供了一个独特的模型。在此，我们报告了两名来自同一脑死亡供体的SLT受者，其中只有一人发生了非酒精性脂肪性肝炎（NASH），这表明宿主因素对NASH的发生至关重要。