Vennin Claire, Herrmann David, Lucas Morghan C, Timpson Paul
The Kinghorn Cancer Centre, Cancer Division, The Garvan Institute of Medical Research, Sydney, NSW, Australia.
St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
F1000Res. 2016 May 16;5. doi: 10.12688/f1000research.8090.1. eCollection 2016.
Intravital imaging is providing new insights into the dynamics of tumor progression in native tissues and has started to reveal the layers of complexity found in cancer. Recent advances in intravital imaging have allowed us to look deeper into cancer behavior and to dissect the interactions between tumor cells and the ancillary host niche that promote cancer development. In this review, we provide an insight into the latest advances in cancer biology achieved by intravital imaging, focusing on recently discovered mechanisms by which tumor cells manipulate normal tissue to facilitate disease progression.
活体成像为深入了解天然组织中肿瘤进展的动态过程提供了新的视角，并已开始揭示癌症中存在的复杂层面。活体成像的最新进展使我们能够更深入地观察癌症行为，并剖析肿瘤细胞与促进癌症发展的辅助宿主微环境之间的相互作用。在这篇综述中，我们深入探讨了通过活体成像在癌症生物学方面取得的最新进展，重点关注肿瘤细胞操纵正常组织以促进疾病进展的最新发现机制。
