Department of Surgery, Hubei Key Laboratory of Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.
Int J Cancer. 2014 Oct 1;135(7):1511-6. doi: 10.1002/ijc.28632. Epub 2013 Dec 7.
Biobanks have played a decisive role in all aspects of the field of cancer, including pathogenesis, diagnosis, prognosis and treatment. The significance of cancer biobanks is epitomized through the appropriate application of various "-omic" techniques (omics). The mutually motivated relationship between biobanks and omics has intensified the development of cancer research. Human cancer tissues that are maintained in intravital biobanks (or living tissue banks) retain native tumor microenvironment, tissue architecture, hormone responsiveness and cell-to-cell signalling properties. Intravital biobanks replicate the structural complexity and heterogeneity of human cancers, making them an ideal platform for preclinical studies. The application of omics with intravital biobanks renders them more active, which makes it possible for the cancer-related evaluations to be dynamically monitored on a real-time basis. Integrating intravital biobank and modern omics will provide a useful tool for the discovery and development of new drugs or novel therapeutic strategies. More importantly, intravital biobanks may play an essential role in the creation of meaningful patient-tailored therapies as for personalized medicine.
生物银行在癌症领域的各个方面都发挥了决定性作用，包括发病机制、诊断、预后和治疗。癌症生物银行的意义通过各种“组学”技术（组学）的适当应用得到了体现。生物银行和组学之间相互促进的关系促进了癌症研究的发展。保存在活体生物银行（或活体组织库）中的人类癌症组织保留了天然的肿瘤微环境、组织架构、激素反应性和细胞间信号传递特性。活体生物银行复制了人类癌症的结构复杂性和异质性，使其成为临床前研究的理想平台。将组学与活体生物银行结合使用，使它们更加活跃，从而可以实时动态监测与癌症相关的评估。整合活体生物银行和现代组学将为新药或新治疗策略的发现和开发提供有用的工具。更重要的是，活体生物银行可能在创建有意义的个体化治疗方法方面发挥重要作用，以实现个性化医疗。
