癌症转移的系统生物学。
Systems Biology of Cancer Metastasis.
机构信息
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA; Cancer Systems Biology @ Yale (CaSB@Yale), Yale University, West Haven, CT, USA.
Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Cell Syst. 2019 Aug 28;9(2):109-127. doi: 10.1016/j.cels.2019.07.003.
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.
癌症转移不再被视为一系列线性事件的级联，而是一系列同时发生的、部分重叠的过程，因为成功转移的细胞在抛弃旧行为的同时，会获得新的表型。由于缺乏对这种复杂现象的系统认识，因此在开发转移性疾病治疗方法方面进展有限。由于转移通常在不同的生理隔室中进行研究，因此将这些复杂且相互关联的方面整合在一起仍然是转移性疾病系统水平实验和计算建模的挑战。在这里，我们介绍了癌症转移复杂性的一些当前观点，其进展的多尺度性质，以及癌症细胞侵袭性扩散背后过程的系统水平观点。我们还强调了我们目前对癌症转移理解的差距，以及从跨学科系统生物学方法中出现的理解这一复杂现象的新见解。
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