• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2006年至2012年在德黑兰法拉比眼科医院对274例结膜肿瘤性病变患者进行的调查。

Survey of 274 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran 2006-2012.

作者信息

Asadi-Amoli Fahimeh, Ghanadan Alireza

机构信息

Department of Pathology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Department of Pathology, Razi Skin Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Curr Ophthalmol. 2015 Oct 31;27(1-2):37-40. doi: 10.1016/j.joco.2015.09.007. eCollection 2015 Mar-Jun.

DOI:10.1016/j.joco.2015.09.007
PMID:27239573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4877714/
Abstract

PURPOSE

To evaluate conjunctival epithelial neoplastic lesions in a 7-year period.

MATERIALS AND METHODS

The data of all primary cases of conjunctival neoplasia diagnosed in the Pathology Department of Farabi Eye Hospital were analyzed.

RESULTS

The patient group consisted of 179 (65.3%) males and 95 (34.6%) females, with an age range of 14-90 years and a mean age of 57.9 years. The most common primary conjunctival epithelial neoplastic lesion was invasive squamous cell carcinoma (SCC) (40.8%), followed by dysplasia (17%), papilloma (16.4%), In situ SCC (16%), actinic keratosis (7.3%), basal cell carcinoma (0.7%), xeroderma pigmentosum (0.7%), and mucoepidermoid carcinoma (0.3%). Of 274 lesions, 47 (17.1%) were benign, 159 (58%) were malignant, and 68 (24.8%) were precancerous. Compared to the results of a previous study of this center (1990-2004), the incidence of precancerous lesions has slightly increased whereas the incidence of SCC has decreased (22.1% vs. 24.8% and 59% vs. 40.8%, respectively).

CONCLUSION

SCC is the most common conjunctival epithelial neoplasm in this study, and its prevalence in males is nearly two times higher than in females. The high percentage of squamous cell carcinoma can likely be attributed to elevated sun exposure and ultraviolet light in Iran.

摘要

目的

评估7年间结膜上皮肿瘤性病变情况。

材料与方法

对法拉比眼科医院病理科诊断的所有结膜肿瘤原发性病例的数据进行分析。

结果

患者组包括179名男性（65.3%）和95名女性（34.6%），年龄范围为14至90岁，平均年龄为57.9岁。最常见的原发性结膜上皮肿瘤性病变是浸润性鳞状细胞癌（SCC）（40.8%），其次是发育异常（17%）、乳头状瘤（16.4%）、原位SCC（16%）、光化性角化病（7.3%）、基底细胞癌（0.7%）、着色性干皮病（0.7%）和黏液表皮样癌（0.3%）。在274个病变中，47个（17.1%）为良性，159个（58%）为恶性，68个（24.8%）为癌前病变。与该中心之前一项研究（1990 - 2004年）的结果相比，癌前病变的发生率略有上升，而SCC的发生率有所下降（分别为22.1%对24.8%和59%对40.8%）。

结论

在本研究中，SCC是最常见的结膜上皮肿瘤，其在男性中的患病率几乎是女性的两倍。鳞状细胞癌的高比例可能归因于伊朗阳光照射和紫外线水平的升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d72b/4877714/01ed874493e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d72b/4877714/01ed874493e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d72b/4877714/01ed874493e6/gr1.jpg

相似文献

1
Survey of 274 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran 2006-2012.2006年至2012年在德黑兰法拉比眼科医院对274例结膜肿瘤性病变患者进行的调查。
J Curr Ophthalmol. 2015 Oct 31;27(1-2):37-40. doi: 10.1016/j.joco.2015.09.007. eCollection 2015 Mar-Jun.
2
Survey of 447 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran, Iran.伊朗德黑兰法拉比眼科医院447例结膜肿瘤性病变患者的调查。
Ophthalmic Epidemiol. 2006 Aug;13(4):275-9. doi: 10.1080/09286580600801036.
3
A clinicopathologic study of excised conjunctival lesions.结膜切除病变的临床病理研究
Middle East Afr J Ophthalmol. 2011 Jan;18(1):48-54. doi: 10.4103/0974-9233.75886.
4
Conjunctival Lesions; a Histopathologic Review in Fars Province, Iran.结膜病变；伊朗法尔斯省的组织病理学回顾
J Ophthalmic Vis Res. 2015 Apr-Jun;10(2):98-101. doi: 10.4103/2008-322X.163774.
5
Incidence of epithelial lesions of the conjunctiva in a review of 12,102 specimens in Canada (Quebec).对加拿大（魁北克）12,102份标本进行回顾研究时结膜上皮病变的发病率。
Arq Bras Oftalmol. 2011 Jan-Feb;74(1):21-3. doi: 10.1590/s0004-27492011000100005.
6
Detection of human papillomavirus in squamous cell carcinoma of conjunctiva by nested PCR: a case control study in Iran.通过巢式聚合酶链反应检测结膜鳞状细胞癌中的人乳头瘤病毒：伊朗的一项病例对照研究
Acta Med Iran. 2011;49(11):707-14.
7
Prevalence of HIV with conjunctival squamous cell neoplasia in an African provincial hospital.非洲某省级医院中感染艾滋病毒并患有结膜鳞状细胞瘤的情况。
Cornea. 2003 Jan;22(1):1-4. doi: 10.1097/00003226-200301000-00001.
8
Actinic keratosis and dysplasia of the conjunctiva: a clinicopathological study of 45 cases.
Can J Ophthalmol. 1995 Oct;30(6):312-6.
9
Cyclin A and beta-catenin expression in actinic keratosis, Bowen's disease and invasive squamous cell carcinoma of the skin.细胞周期蛋白A和β-连环蛋白在光化性角化病、鲍恩病及皮肤浸润性鳞状细胞癌中的表达
Br J Dermatol. 2005 Dec;153(6):1166-75. doi: 10.1111/j.1365-2133.2005.06898.x.
10
Predictors of Ocular Surface Squamous Neoplasia and Conjunctival Squamous Cell Carcinoma among Ugandan Patients: A Hospital-based Study.乌干达患者眼表鳞状上皮瘤和结膜鳞状细胞癌的预测因素：一项基于医院的研究。
Middle East Afr J Ophthalmol. 2018 Jul-Dec;25(3-4):150-155. doi: 10.4103/meajo.MEAJO_187_16.

引用本文的文献

1
Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence.利用人工智能对眼表鳞状细胞癌进行新型自动化无创检测。
World J Methodol. 2024 Jun 20;14(2):92267. doi: 10.5662/wjm.v14.i2.92267.
2
Clinical features and factors affecting prognosis and partial deterioration of ocular papilloma: a retrospective study of 298 cases.临床特征及影响眼内乳头状瘤预后和部分恶化的因素：298 例回顾性研究。
Graefes Arch Clin Exp Ophthalmol. 2023 Aug;261(8):2395-2402. doi: 10.1007/s00417-023-06035-y. Epub 2023 Mar 18.
3
The Management of Ocular Surface Squamous Neoplasia (OSSN).

本文引用的文献

1
Incidence of squamous-cell carcinoma of the conjunctiva and other eye cancers in the NIH-AARP Diet and Health Study.美国国立卫生研究院-美国退休人员协会饮食与健康研究中结膜鳞状细胞癌及其他眼部癌症的发病率。
Ecancermedicalscience. 2012;6:254. doi: 10.3332/ecancer.2012.254. Epub 2012 May 21.
2
Detection of human papillomavirus in squamous cell carcinoma of conjunctiva by nested PCR: a case control study in Iran.通过巢式聚合酶链反应检测结膜鳞状细胞癌中的人乳头瘤病毒：伊朗的一项病例对照研究
Acta Med Iran. 2011;49(11):707-14.
3
Low frequency of human papillomavirus infection in conjunctival squamous cell carcinoma of Mexican patients.
眼表鳞状细胞肿瘤（OSSN）的处理。
Int J Mol Sci. 2022 Dec 31;24(1):713. doi: 10.3390/ijms24010713.
4
Conjunctival papilloma treatment outcomes: a 12-year-retrospective study.结膜乳头瘤的治疗结果：一项 12 年回顾性研究。
Eye (Lond). 2023 Apr;37(5):977-982. doi: 10.1038/s41433-022-02329-3. Epub 2022 Dec 5.
5
Ocular surface squamous neoplasia in Northern Thailand: a 16-year review.泰国北部的眼表鳞状细胞肿瘤：16 年回顾。
BMC Ophthalmol. 2022 Mar 12;22(1):121. doi: 10.1186/s12886-022-02340-y.
6
Conjunctival Lesions: A 5-Year Basic Demographic Data and Clinicopathological Review in a Tertiary Eye Care Hospital.结膜病变：一家三级眼科医院 5 年的基本人口统计学数据和临床病理回顾。
J Epidemiol Glob Health. 2022 Mar;12(1):25-39. doi: 10.1007/s44197-021-00017-1. Epub 2021 Nov 30.
7
Update on Diagnosis and Management of Conjunctival Papilloma.结膜乳头状瘤的诊断与管理最新进展
Eye Vis (Lond). 2019 Jun 18;6:18. doi: 10.1186/s40662-019-0142-5. eCollection 2019.
8
Characteristics, management, and outcome of squamous carcinoma of the conjunctiva in a single tertiary cancer center in Jordan.约旦一家三级癌症中心结膜鳞状细胞癌的特征、治疗及预后
Int J Ophthalmol. 2018 Jul 18;11(7):1132-1138. doi: 10.18240/ijo.2018.07.10. eCollection 2018.
墨西哥患者结膜鳞状细胞癌中人乳头瘤病毒感染的低频率。
Infect Agent Cancer. 2011 Nov 18;6:24. doi: 10.1186/1750-9378-6-24.
4
Incidence of epithelial lesions of the conjunctiva in a review of 12,102 specimens in Canada (Quebec).对加拿大（魁北克）12,102份标本进行回顾研究时结膜上皮病变的发病率。
Arq Bras Oftalmol. 2011 Jan-Feb;74(1):21-3. doi: 10.1590/s0004-27492011000100005.
5
Human papillomavirus infection and squamous cell carcinoma of the conjunctiva.人乳头瘤病毒感染与结膜鳞状细胞癌。
Br J Cancer. 2010 Jan 19;102(2):262-7. doi: 10.1038/sj.bjc.6605466. Epub 2009 Dec 8.
6
Genital and cutaneous human papillomavirus (HPV) types in relation to conjunctival squamous cell neoplasia: a case-control study in Uganda.与结膜鳞状细胞肿瘤相关的生殖器和皮肤人乳头瘤病毒（HPV）类型：乌干达的一项病例对照研究
Infect Agent Cancer. 2008 Sep 10;3:12. doi: 10.1186/1750-9378-3-12.
7
The role of infectious agents in the etiology of ocular adnexal neoplasia.感染因子在眼附属器肿瘤病因学中的作用。
Surv Ophthalmol. 2008 Jul-Aug;53(4):312-31. doi: 10.1016/j.survophthal.2008.04.008.
8
Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States.美国艾滋病成年患者患结膜鳞状细胞癌的风险升高。
Int J Cancer. 2008 Jun 1;122(11):2590-3. doi: 10.1002/ijc.23384.
9
Survey of 447 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran, Iran.伊朗德黑兰法拉比眼科医院447例结膜肿瘤性病变患者的调查。
Ophthalmic Epidemiol. 2006 Aug;13(4):275-9. doi: 10.1080/09286580600801036.
10
Ocular surface squamous neoplasia.眼表鳞状上皮肿瘤
Ophthalmol Clin North Am. 2005 Mar;18(1):1-13, vii. doi: 10.1016/j.ohc.2004.08.001.