通过应用脂质微球将环孢素选择性转运至胸段淋巴系统。

Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres.

作者信息

Yanagawa A, Iwayama T, Saotome T, Shoji Y, Takano K, Oka H, Nakagawa T, Mizushima Y

机构信息

First Department of Internal Medicine, School of Medicine, St. Marianna University, Kanagawa-Pref, Japan.

出版信息

J Microencapsul. 1989 Apr-Jun;6(2):161-4. doi: 10.3109/02652048909098016.

DOI:10.3109/02652048909098016

PMID:2723958

Abstract

To overcome some of the disadvantages of present cyclosporin A (CsA) therapy, lipid microspheres incorporating CsA (lipo-CsA) were designed and their selective transfer to thoracic lymphatic systems was evaluated in vivo. It was found that concentrations of CsA in lymph-ducts were about 46 times higher after 2 h and 9-10 times higher after 3 h following oral administration of lipo-CsA, compared with those of conventional CsA. The concentrations in plasma produced by lipo-CsA were also higher than those produced by conventional CsA.

摘要

为克服目前环孢素A（CsA）疗法的一些缺点，设计了包载CsA的脂质微球（lipo-CsA），并在体内评估了它们向胸淋巴系统的选择性转运。结果发现，口服lipo-CsA后2小时，淋巴管中CsA的浓度比传统CsA高约46倍，3小时后高9至10倍。lipo-CsA产生的血浆浓度也高于传统CsA产生的浓度。