Porter C J
Department of Pharmaceutics, Victorian College of Pharmacy, Monash, Australia.
Crit Rev Ther Drug Carrier Syst. 1997;14(4):333-93.
The specialized structure and function of the lymphatics has stimulated considerable interest in both site-specific drug delivery to the lymph and lymphoid tissue, and delivery to the systemic circulation via lymphatic transport mechanisms. In this review, drug access to the lymphatic system from the vasculature or interstitium after parenteral administration, and from the gastrointestinal tract after enteral administration, is discussed. Macromolecular and lipophilic prodrug approaches to lymphatic delivery and the use of microparticulate systems such as microspheres, liposomes, and colloidal carbon are also examined and discussed.
淋巴管的特殊结构和功能激发了人们对药物向淋巴和淋巴组织进行部位特异性递送，以及通过淋巴转运机制向体循环递送的浓厚兴趣。在这篇综述中，讨论了药物经肠胃外给药后从脉管系统或间质进入淋巴系统，以及经肠内给药后从胃肠道进入淋巴系统的情况。还研究并讨论了用于淋巴递送的大分子和亲脂性前药方法，以及微球、脂质体和胶体碳等微粒系统的应用。
