糖尿病、尿崩症、视神经萎缩和耳聋：一例沃尔弗勒姆（DIDMOAD）综合征病例。
Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome.
作者信息
Maleki Nasrollah, Bashardoust Bahman, Zakeri Anahita, Salehifar Azita, Tavosi Zahra
机构信息
Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Department of Internal Medicine, Shohadaye Khalije Fars Hospital, Bushehr University of Medical Sciences Bushehr, Iran.
出版信息
J Curr Ophthalmol. 2016 Jan 2;27(3-4):132-5. doi: 10.1016/j.joco.2015.11.003. eCollection 2015 Sep-Dec.
PURPOSE
To report a case of Wolfram syndrome (WS) characterized by diabetes mellitus, diabetes insipidus, progressive optic atrophy, and deafness.
CASE REPORT
A 19-year-old female patient, a known case of diabetes mellitus type I from six years before, presented with progressive vision loss since four years earlier. On fundoscopic examination, she had bilateral optic atrophy without diabetic retinopathy. The patient also had diabetes insipidus, neurosensory deafness, and neurogenic bladder.
CONCLUSION
WS should be considered a differential diagnosis in patients with diabetes mellitus who present with optic atrophy, and it is necessary to perform a hearing test as well as collecting 24-h urine output.
目的
报告一例以糖尿病、尿崩症、进行性视神经萎缩和耳聋为特征的Wolfram综合征（WS）。
病例报告
一名19岁女性患者，6年前确诊为I型糖尿病，4年前开始出现进行性视力丧失。眼底检查显示，她患有双侧视神经萎缩，无糖尿病视网膜病变。该患者还患有尿崩症、神经性耳聋和神经源性膀胱。
结论
对于患有视神经萎缩的糖尿病患者，应考虑将WS作为鉴别诊断，并且有必要进行听力测试以及收集24小时尿量。
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