Liposomes as cyclosporin A carriers: positively charged lecithin-cholesterol liposomes associated with cyclosporin A do not inhibit biosynthesis of mitochondrial polyglycerophosphatides and microsomal phosphatidylinositol.

Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and microsomal membranes, respectively, isolated from rat liver. These results are explained by possible protection of the liposomes by cyclosporin A against phospholipase A2 hydrolysis.