Prapaitrakul W, Whitworth C W
College of Pharmacy, University of Cincinnati, OH 45267.
J Microencapsul. 1989 Apr-Jun;6(2):213-8. doi: 10.3109/02652048909098023.
Phenylpropanolamine HCl was initially microencapsulated with cellulose acetate butyrate, however, the microcapsules did not show acceptable sustained release. A reduction of the drug particle size prior to microencapsulation resulted in a reduction in drug release rate from the microcapsules. The desired drug release profile was attained only when the drug powder was replaced with a drug-resin complex in the microencapsulation process. The pH of the dissolution media had an effect on the drug release profile.
盐酸苯丙醇胺最初用醋酸丁酸纤维素进行微囊化，但微囊并未显示出可接受的缓释效果。微囊化前减小药物粒径会导致微囊中药物释放速率降低。只有在微囊化过程中用药物-树脂复合物替代药物粉末时，才能获得所需的药物释放曲线。溶出介质的pH值对药物释放曲线有影响。
