Moral L, Toral T
Pediatric Allergy and Respiratory Unit, Hospital General Universitario de Alicante, Alicante, Spain.
Pediatric Allergy and Respiratory Unit, Hospital General Universitario de Alicante, Alicante, Spain.
Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):427-32. doi: 10.1016/j.aller.2016.02.004. Epub 2016 May 27.
Sensitisation to home aeroallergens (mites, furry animals and cockroaches) is predominant in patients in our and other areas. Covariation of sensitisation (CS) to these allergens could be due to cross-reactivity or parallel sensitisation.
Skin prick tests were performed to common and second-line home aeroallergens, shrimp and tropomyosin in 253 paediatric patients seen in our Unit due to chronic respiratory symptoms. CS among the main allergens was analysed by means of Cohen's kappa coefficient of concordance (κ).
House dust mites (HDM) were the main allergens involved in sensitisation, followed by furry animals, pollens, storage mites (SM), moulds and cockroaches. CS was very good between D. pteronyssinus and D. farinae (κ=0.81), and good between Dermatophagoides and Euroglyphus (κ=0.71), and decreased markedly to poor (κ<0.20) between HDM and SM or cockroaches. CS among SM and cockroaches was moderate to fair (κ=0.21-0.44). CS was good between shrimp and tropomyosin (κ=0.62), but null between shrimp-tropomyosin and HDM (κ=0.01-0.02), and poor to fair between shrimp-tropomyosin and SM or cockroaches (κ=0.06-0.34). CS between cat and dog was moderate (κ=0.50).
We have shown the usefulness of κ in exploring CS in a population. In our area, with high sensitisation to HDM and other home allergens, CS is limited for most pairs of allergens, pointing to a lower incidence of cross-reactivity than could be expected, especially between HDM and SM or other invertebrates.
在我们地区及其他地区的患者中，对家庭空气过敏原（螨虫、带毛动物和蟑螂）致敏的情况占主导。对这些过敏原的致敏共变（CS）可能是由于交叉反应或平行致敏。
对因慢性呼吸道症状前来我们科室就诊的253名儿科患者进行了针对常见和二线家庭空气过敏原、虾和原肌球蛋白的皮肤点刺试验。主要过敏原之间的CS通过科恩一致性kappa系数（κ）进行分析。
屋尘螨（HDM）是致敏涉及的主要过敏原，其次是带毛动物、花粉、仓储螨（SM）、霉菌和蟑螂。D. pteronyssinus和D. farinae之间的CS非常好（κ = 0.81），Dermatophagoides和Euroglyphus之间的CS良好（κ = 0.71），而HDM与SM或蟑螂之间的CS则显著下降至较差（κ < 0.20）。SM和蟑螂之间的CS为中等至尚可（κ = 0.21 - 0.44）。虾和原肌球蛋白之间的CS良好（κ = 0.62），但虾 - 原肌球蛋白与HDM之间的CS为零（κ = 0.01 - 0.02），虾 - 原肌球蛋白与SM或蟑螂之间的CS为差至尚可（κ = 0.06 - 0.34）。猫和狗之间的CS为中等（κ = 0.50）。
我们已经证明κ在探索人群中的CS方面是有用的。在我们地区，对HDM和其他家庭过敏原致敏率较高，大多数过敏原对之间的CS有限，这表明交叉反应的发生率低于预期，特别是在HDM与SM或其他无脊椎动物之间。
