Wyczalkowska-Tomasik Aleksandra, Czarkowska-Paczek Bozena, Giebultowicz Joanna, Wroczynski Piotr, Paczek Leszek
Department of Immunology, Transplantology, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Department of Clinical Nursing, Medical University of Warsaw, Warsaw, Poland.
Geriatr Gerontol Int. 2017 Jun;17(6):1022-1026. doi: 10.1111/ggi.12811. Epub 2016 May 31.
Retention of indoxyl sulphate and p-cresol sulphate is associated with many diseases. The aim of the present study was to examine serum levels of indoxyl sulphate and p-cresol sulphate, the dynamics of their changes according to age, and their precursors.
The study included 180 healthy individuals aged 20-90 years (n = 180), divided into subgroups by decade (n = 30 in each subgroup) and into subgroups of ≥65 years (n = 42) or <65 years (n = 138). Serum indoxyl sulphate and p-cresol sulphate, tryptophan, and tyrosine were measured using high-performance liquid chromatography-mass spectrometry.
The 70-90 years age group had higher indoxyl sulphate than the 50-59 years age group (P = 0.033). The 70-90 years age group had higher p-cresol sulphate than the 20-29 years (P < 0.001), 30-39 years (P < 0.001), 40-49 years (P = 0.007) and 50-59 years (P = 0.001) age groups; the 60-69 years age group had higher p-cresol sulphate than the 20-29 years (P = 0.043) and 30-39 years (P = 0.011) age groups. Indoxyl sulphate and p-cresol sulphate serum levels were higher in those aged ≥65 years. Indoxyl sulphate and p-cresol sulphate serum levels correlated positively with age, but not with tryptophan and tyrosine, respectively.
Healthy aging is associated with indoxyl sulphate and p-cresol sulphate serum level increases, which are not linked to tryptophan and tyrosine serum levels. Geriatr Gerontol Int 2017; 17: 1022-1026.
硫酸吲哚酚和对甲酚硫酸酯的潴留与多种疾病相关。本研究旨在检测血清中硫酸吲哚酚和对甲酚硫酸酯的水平、其随年龄变化的动态情况及其前体物质。
该研究纳入了180名年龄在20 - 90岁的健康个体（n = 180），按十年为一组分为亚组（每组n = 30），并分为≥65岁亚组（n = 42）和<65岁亚组（n = 138）。采用高效液相色谱 - 质谱法测定血清中的硫酸吲哚酚、对甲酚硫酸酯、色氨酸和酪氨酸。
70 - 90岁年龄组的硫酸吲哚酚水平高于50 - 59岁年龄组（P = 0.033）。70 - 90岁年龄组的对甲酚硫酸酯水平高于20 - 29岁（P < 0.001）、30 - 39岁（P < 0.001）、40 - 49岁（P = 0.007）和50 - 59岁（P = 0.001）年龄组；60 - 69岁年龄组的对甲酚硫酸酯水平高于20 - 29岁（P = 0.043）和30 - 39岁（P = 0.011）年龄组。≥65岁人群的血清硫酸吲哚酚和对甲酚硫酸酯水平较高。血清硫酸吲哚酚和对甲酚硫酸酯水平与年龄呈正相关，但分别与色氨酸和酪氨酸无关。
健康老龄化与血清硫酸吲哚酚和对甲酚硫酸酯水平升高有关，且这与血清色氨酸和酪氨酸水平无关。《老年医学与老年病学国际杂志》2017年；17: 1022 - 1026。
