Marras Connie, Lang Anthony E, Austin Peter C, Lau Cindy, Urbach David R
Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada, University of Toronto, Toronto, Ontario, Canada.
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Mov Disord. 2016 Aug;31(8):1243-7. doi: 10.1002/mds.26670. Epub 2016 May 31.
Pathogenic movement of alpha-synuclein from the gut to the brain in PD has been proposed. The appendix has a relatively high density of alpha-synuclein deposition in neurologically healthy individuals. We investigated the incidence of PD after appendectomy.
Using cause-specific hazards regression models, we compared persons over 35 years of age who had undergone appendectomy with two groups of age- and sex-matched individuals having had: (1) a cholecystectomy and (2) neither procedure. Subsequent diagnoses of PD were identified.
Among 42,999 individuals undergoing appendectomy, no difference in risk of PD was identified compared to cholecystectomy (hazard ratio = 1.004; 95% confidence interval: 0.740-1.364). Compared with no procedure, individuals with appendectomy had a higher incidence of PD within 5 years, but no significant difference in risk thereafter.
In our study, appendectomy in mid or late life does not appear to be associated with a reduced risk of PD. © 2016 International Parkinson and Movement Disorder Society.
已有研究提出帕金森病（PD）中α-突触核蛋白从肠道向大脑的致病性转移。在神经功能正常的个体中，阑尾具有相对较高密度的α-突触核蛋白沉积。我们调查了阑尾切除术后PD的发病率。
使用特定病因风险回归模型，我们将35岁以上接受阑尾切除术的人与两组年龄和性别匹配的个体进行了比较，这两组个体分别为：（1）接受胆囊切除术的个体和（2）未接受任何手术的个体。确定随后的PD诊断。
在42999例接受阑尾切除术的个体中，与胆囊切除术相比，未发现PD风险存在差异（风险比=1.004；95%置信区间：0.740-1.364）。与未接受任何手术的个体相比，接受阑尾切除术的个体在5年内PD发病率较高，但此后风险无显著差异。
在我们的研究中，中年或晚年进行阑尾切除术似乎与降低PD风险无关。©2016国际帕金森病和运动障碍协会。
Zotero 插件