阑尾切除术与帕金森病风险：一项韩国全国性研究。
Appendectomy and the Risk of Parkinson's Disease: A Korean Nationwide Study.
机构信息
Pacific Parkinson Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Preventive Medicine, Keimyung University School of Medicine, Daegu, Korea.
出版信息
Mov Disord Clin Pract. 2024 Jun;11(6):704-707. doi: 10.1002/mdc3.14031. Epub 2024 May 2.
BACKGROUND
The vermiform appendix is considered a potential reservoir for the abnormal α-synuclein aggregate in Parkinson's disease (PD). Previous epidemiologic evidence on the association between appendectomy and PD risk remains inconclusive, especially outside the Western world.
OBJECTIVES
To investigate the association between appendectomy and PD risk in Korea.
METHODS
Among 703,831 eligible adult subjects in the National Health Insurance Service sample cohort, we identified 16,122 patients who underwent appendectomy. The rest formed the control group. PD risk was assessed using time-dependent Cox regression analyses.
RESULTS
The appendectomy group did not have altered risk of PD compared with the control group in either unadjusted [hazard ratio (HR) 1.32, 95% confidence interval (CI) 0.97-1.80, P = 0.08] or adjusted model (HR 1.42, CI 0.88-2.30, P = 0.15). No further statistical difference appeared when stratified by sex.
CONCLUSIONS
Appendectomy is not associated with altered risk of PD in the Korean population.
背景
阑尾被认为是帕金森病（PD）中异常α-突触核蛋白聚集的潜在储库。阑尾切除术与 PD 风险之间的关联的先前流行病学证据仍然没有定论，尤其是在西方世界以外。
目的
在韩国调查阑尾切除术与 PD 风险之间的关联。
方法
在国家健康保险服务样本队列中，我们从 703831 名合格的成年受试者中确定了 16122 名接受过阑尾切除术的患者。其余的人组成对照组。使用时间依赖性 Cox 回归分析评估 PD 风险。
结果
与对照组相比，阑尾切除术组在未调整模型（危险比 [HR] 1.32，95%置信区间 [CI] 0.97-1.80，P=0.08）或调整模型（HR 1.42，CI 0.88-2.30，P=0.15）中均未显示出改变的 PD 风险。按性别分层时，也没有出现进一步的统计学差异。
结论
在韩国人群中，阑尾切除术与 PD 风险增加无关。
Zotero 插件