Chin Hok Leong, Tsang Yiu Sing, Shi Haojun
Section of Neurology, Department of Pediatrics, University of Chicago Medicine, Chicago, IL, United States.
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Front Neurol. 2025 Jul 21;16:1619236. doi: 10.3389/fneur.2025.1619236. eCollection 2025.
Braak's hypothesis suggests that α-synuclein may enter the central nervous system through the enteric nervous system and contribute to the pathogenesis of Parkinson's disease (PD). The appendix, enriched in α-synuclein, has been proposed as a possible entry point in PD pathogenesis. This systematic review and meta-analysis aimed to assess the association between appendectomy and PD risk using newly available data.
A literature search was conducted in PubMed and Embase through September 10, 2024, to identify studies on appendectomy and PD risk. Two independent reviewers screened and assessed articles for eligibility with a third reviewer involved in cases of disagreement. Study quality was assessed using the Newcastle-Ottawa Scale. Data for meta-analysis were pooled using a random-effects model and analyzed in Review Manager 5.4. Meta-regression, subgroup, and sensitivity analyses were performed.
Nine studies met inclusion criteria. Meta-analysis indicated no significant association between appendectomy and PD risk (RR: 1.01, 95% CI: 0.90-1.12, = 0.89). Subgroup analyses showed similar findings. Sensitivity analyses did not change the estimate.
This analysis suggests no association between appendectomy and PD risk.
布拉克假说认为，α-突触核蛋白可能通过肠神经系统进入中枢神经系统，并参与帕金森病（PD）的发病机制。富含α-突触核蛋白的阑尾已被提出可能是PD发病机制中的一个切入点。本系统评价和荟萃分析旨在利用最新可得数据评估阑尾切除术与PD风险之间的关联。
截至2024年9月10日，在PubMed和Embase中进行文献检索，以识别关于阑尾切除术与PD风险的研究。两名独立评审员筛选并评估文章的合格性，如有分歧则由第三名评审员参与。使用纽卡斯尔-渥太华量表评估研究质量。荟萃分析的数据采用随机效应模型合并，并在Review Manager 5.4中进行分析。进行了meta回归、亚组分析和敏感性分析。
九项研究符合纳入标准。荟萃分析表明阑尾切除术与PD风险之间无显著关联（RR：1.01，95%CI：0.90-1.12， = 0.89）。亚组分析显示了类似的结果。敏感性分析未改变估计值。
该分析表明阑尾切除术与PD风险之间无关联。
