Pediatric Endocrine Unit, Hospital de Clinicas Caracas, Avenida Panteon, San Bernardino, Caracas, Venezuela.
Endocrinol Metab Clin North Am. 2016 Jun;45(2):405-18. doi: 10.1016/j.ecl.2016.01.005. Epub 2016 Apr 7.
Growth hormone deficiency (GHD) in adulthood is associated with an increased risk of developing adverse cardiovascular events and with reduced life expectancy. Cardiovascular and metabolic abnormalities have so far been evaluated only in a small number of children with GHD and adolescents. In this article we review these abnormalities and their underlying mechanisms and discuss the beneficial effect of growth hormone treatment in subjects with GHD.
成人生长激素缺乏症（GHD）与发生不良心血管事件的风险增加以及预期寿命缩短有关。迄今为止，仅在少数患有 GHD 的儿童和青少年中评估了心血管和代谢异常。在本文中，我们回顾了这些异常及其潜在机制，并讨论了生长激素治疗对 GHD 患者的有益作用。
