噻唑烷二酮类抗糖尿病药物与抗高脂血症药物联合使用者发生严重低血糖的比较风险。
Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics.
作者信息
Leonard Charles E, Han Xu, Bilker Warren B, Flory James H, Brensinger Colleen M, Flockhart David A, Gagne Joshua J, Cardillo Serena, Hennessy Sean
机构信息
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States; Center for Pharmacoepidemiology Research and Training, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States.
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States; Center for Pharmacoepidemiology Research and Training, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States.
出版信息
Diabetes Res Clin Pract. 2016 May;115:60-7. doi: 10.1016/j.diabres.2016.03.006. Epub 2016 Mar 14.
We conducted high-dimensional propensity score-adjusted cohort studies to examine whether thiazolidinedione use with a statin or fibrate was associated with an increased risk of severe hypoglycemia. We found that concomitant therapy with a thiazolidinedione+fibrate was associated with a generally delayed increased risk of severe hypoglycemia.
我们进行了高维倾向评分调整队列研究，以检验噻唑烷二酮与他汀类药物或贝特类药物联合使用是否与严重低血糖风险增加相关。我们发现，噻唑烷二酮与贝特类药物联合治疗通常与严重低血糖风险延迟增加相关。
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