Albrecht Matthew A, Masters Colin L, Ames David, Foster Jonathan K
School of Public Health, Curtin UniversityPerth, WA, Australia; Curtin Health Innovation Research Institute - BiosciencesPerth, WA, Australia; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of MedicineBaltimore, MD, USA.
Mental Health Research Institute, The University of Melbourne Parkville, VIC, Australia.
Front Aging Neurosci. 2016 May 12;8:105. doi: 10.3389/fnagi.2016.00105. eCollection 2016.
Traumatic brain injury (TBI) is suggested to be a significant risk factor for dementia. However, little research has been conducted into long-term neuropsychological outcomes after head trauma. Participants from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) who had recovered after sustaining a mild TBI involving loss of consciousness more than 5 years previously were compared with matched controls across a 3-year period. Bayesian nested-domain modeling was used to estimate the effect of TBI on neuropsychological performance. There was no evidence for a chronic effect of mild TBI on any neuropsychological domain compared to controls. Within the TBI group, there was some evidence suggesting that the age that the head trauma occurred and the duration of unconsciousness were modulators of episodic memory. However, these findings were not robust. Taken together, these findings indicate that adults who have sustained a TBI resulting in loss of consciousness, but who recover to a healthy level of cognitive functioning, do not experience frank deficits in cognitive ability.
创伤性脑损伤（TBI）被认为是痴呆症的一个重要风险因素。然而，针对头部创伤后长期神经心理结果的研究却很少。将澳大利亚衰老成像、生物标志物和生活方式研究（AIBL）中5年多前因轻度TBI导致意识丧失后已康复的参与者与匹配的对照组在3年时间内进行比较。采用贝叶斯嵌套域模型来估计TBI对神经心理表现的影响。与对照组相比，没有证据表明轻度TBI对任何神经心理领域有慢性影响。在TBI组中，有一些证据表明头部创伤发生的年龄和意识丧失的持续时间是情景记忆的调节因素。然而，这些发现并不稳健。综上所述，这些发现表明，遭受TBI导致意识丧失但恢复到健康认知功能水平的成年人，其认知能力并未出现明显缺陷。
