Spillert C R, Milazzo V J, Pastena J A, Lazaro E J
J Natl Med Assoc. 1989 Jan;81(1):81-3.
Peripheral vascular complications in diabetic patients are extremely variable. It has been suggested that they are related, in part at least, to accelerated blood coagulation. However, a simple test to monitor these changes in coagulability has not been previously described. This article reports that a test in which citrated blood, when incubated with either saline (control) or with endotoxin (to activate the extrinsic pathway) and then subjected to the determination of the recalcification time, can detect minute changes in coagulability. This technique showed that the recalcification times of both saline and endotoxin-incubated blood samples were significantly shorter in a majority of diabetic patients than in controls. These studies substantiate the significant incidence of hypercoagulability in diabetics.
糖尿病患者的外周血管并发症差异极大。有人提出，这些并发症至少部分与血液凝固加速有关。然而，此前尚未描述过用于监测这些凝血性变化的简单测试。本文报告了一项测试，即柠檬酸化血液与生理盐水（对照）或内毒素（激活外源性途径）一起孵育，然后测定再钙化时间，该测试能够检测到凝血性的微小变化。这项技术表明，在大多数糖尿病患者中，生理盐水和内毒素孵育的血液样本的再钙化时间均显著短于对照组。这些研究证实了糖尿病患者中高凝状态的显著发生率。
