Makumbi Fredrick E, Ssempijja Victor, Sekasanvu Joseph, Ssekubugu Robert, Kigozi Godfrey, Watya Stephen, Nakigozi Gertrude, Serwadda David, Wawer Maria, Gray Ronald H
aMakerere University, School of Public Health, College of Health Sciences, Kampala bRakai Health Sciences Program, Entebbe, Uganda cDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
AIDS. 2016 Jun 19;30(10):1669-73. doi: 10.1097/QAD.0000000000001097.
Postcoital genital washing by uncircumcised men may affect the risk of male HIV acquisition.
We assessed the association between self-reported washing after sex in 2976 initially HIV-negative, uncircumcised men enrolled in a prospective cohort study in Rakai, Uganda.
Data from the 2976 participants who reported sexual intercourse in the past 12 months contributed 4290 visits, with 7316.6 person-years of observation during the 2-year follow-up. The overall HIV-incidence was 1.28/100 person-years 95%CI (1.04-1.57). About 91.0% of men reported washing their penis after sex, and their HIV incidence was 1.34/100 person-years (95%CI 1.08-1.66), compared with an incidence of 0.62/100 person-years (95%CI 0.17-1.60) in men who did not wash their penis after intercourse. Using Poisson multivariable regression, the adjusted incidence rate ratio of HIV acquisition associated with postcoital washing was 1.94 (95%CI 0.71-5.29).
Postcoital penile washing, as practiced in this rural African population does not afford protection from HIV acquisition among uncircumcised men, and may increase risk.
未行包皮环切术的男性性交后进行生殖器清洗可能会影响其感染艾滋病毒的风险。
我们评估了乌干达拉凯地区一项前瞻性队列研究中2976名最初艾滋病毒检测呈阴性、未行包皮环切术的男性自我报告的性交后清洗情况之间的关联。
2976名报告在过去12个月中有过性行为的参与者的数据贡献了4290次随访，在2年的随访期间有7316.6人年的观察期。总体艾滋病毒发病率为1.28/100人年，95%置信区间（1.04 - 1.57）。约91.0%的男性报告在性交后清洗阴茎，其艾滋病毒发病率为1.34/100人年（95%置信区间1.08 - 1.66），而性交后未清洗阴茎的男性发病率为0.62/100人年（95%置信区间0.17 - 1.60）。使用泊松多变量回归分析，与性交后清洗相关的艾滋病毒感染调整发病率比为1.94（95%置信区间0.71 - 5.29）。
在这个非洲农村人群中，性交后清洗阴茎并不能保护未行包皮环切术的男性免受艾滋病毒感染，反而可能增加感染风险。
