耐甲氧西林金黄色葡萄球菌：泰国南部两家三级医院患者的一年收集及特征分析

METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS: 1-YEAR COLLECTION AND CHARACTERIZATION FROM PATIENTS IN TWO TERTIARY HOSPITALS, SOUTHERN THAILAND.

作者信息

Bunnueang Natthakul, Kongpheng Sutthiporn, Yadrak Patcharin, Rattanachuay Pattamarat, Khianngam Saowapar, Sukhumungoon Pharanai

出版信息

Southeast Asian J Trop Med Public Health. 2016 Mar;47(2):234-44.

PMID:27244962

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen causing nosocomial and other types of infections worldwide. In a one-year survey of patients in two tertiary hospitals, namely, Maharaj Nakhon Si Thammarat and VachiraPhuket Hospitals, southern Thailand, 64 MRSA strains (prevalence of 8.1%) were obtained mainly from the elderly (> 45 years of age). PCR-based assay revealed high prevalence of virulence genes, femB (30%) and spa (34%), and of SCCmec type II from VachiraPhuket (36%) and Maharaj Nakhon Si Thammarat (38%) Hospitals. The majority of MRSA strains were resistant to clindamycin (98%), erythromycin (95%), gentamicin (84%), and tetracycline (80%), while still sensitive to chloramphenicol, cotrimoxazole, fusidic acid, and vancomycin. These data are important for effective treatment of MRSA-infected patients and for implementing control strategies to prevent spread of MRSA within hospitals.

摘要

耐甲氧西林金黄色葡萄球菌（MRSA）是一种在全球范围内引起医院感染和其他类型感染的重要病原体。在泰国南部的两所三级医院，即玛哈叻那空是贪玛叻医院和普吉瓦吉拉医院，对患者进行了为期一年的调查，共获得64株MRSA菌株（患病率为8.1%），主要来自老年人（>45岁）。基于PCR的检测显示，毒力基因femB（30%）和spa（34%）以及普吉瓦吉拉医院（36%）和玛哈叻那空是贪玛叻医院（38%）的SCCmec II型的患病率较高。大多数MRSA菌株对克林霉素（98%）、红霉素（95%）、庆大霉素（84%）和四环素（80%）耐药，而对氯霉素、复方新诺明、夫西地酸和万古霉素仍敏感。这些数据对于有效治疗MRSA感染患者以及实施控制策略以防止MRSA在医院内传播具有重要意义。