疟疾和巴贝斯虫病血液期寄生虫之间广泛的共同化学敏感性。
Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.
作者信息
Paul Aditya S, Moreira Cristina K, Elsworth Brendan, Allred David R, Duraisingh Manoj T
机构信息
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Infectious Diseases and Pathology, University of Florida, Gainesville, Florida, USA Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
出版信息
Antimicrob Agents Chemother. 2016 Jul 22;60(8):5059-63. doi: 10.1128/AAC.00928-16. Print 2016 Aug.
Abstract
The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in the Malaria Box library. We observed that these parasites share sensitivities to a large fraction of the same inhibitors and we identified compounds with strong babesiacidal activity.
摘要
导致疟疾和巴贝斯虫病的顶复门寄生虫在红细胞内侵入并增殖。为评估常见抗寄生虫治疗的潜力，我们测定了多种疟原虫和巴贝斯虫寄生虫对疟疾盒文库中化学性质多样的抗疟化合物的敏感性。我们观察到这些寄生虫对很大一部分相同的抑制剂具有共同敏感性，并且我们鉴定出了具有强效杀巴贝斯虫活性的化合物。
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