XPA：人类核苷酸切除修复的关键支架蛋白
XPA: A key scaffold for human nucleotide excision repair.
作者信息
Sugitani Norie, Sivley Robert M, Perry Kelly E, Capra John A, Chazin Walter J
机构信息
Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States.
Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States.
出版信息
DNA Repair (Amst). 2016 Aug;44:123-135. doi: 10.1016/j.dnarep.2016.05.018. Epub 2016 May 20.
Abstract
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.
摘要
核苷酸切除修复（NER）对于从基因组中去除多种类型的DNA损伤至关重要，然而人类中NER的机制仍知之甚少。本综述总结了我们目前对关键NER蛋白之一XPA的结构、生物化学、相互作用伙伴、机制以及与疾病相关突变的理解。
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本文引用的文献
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Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair.核苷酸切除修复中XPC、TFIIH和XPA对三方DNA损伤的识别与验证
Mol Cell. 2015 Sep 17;59(6):1025-34. doi: 10.1016/j.molcel.2015.08.012.
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A novel 5 nucleotide deletion in XPA gene is associated with severe neurological abnormalities.XPA基因中一个新的5核苷酸缺失与严重的神经异常有关。
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Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC.核苷酸切除修复因子XPC酸性序列识别TFIIH机制的结构洞察
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Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA).关于Rad14（XPA）对顺铂和AAF-dG损伤识别的结构见解。
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Xeroderma pigmentosum: low prevalence of germline XPA mutations in a Brazilian XP population.着色性干皮病：巴西着色性干皮病患者群体中种系XPA突变的低发生率
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Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:306-20. doi: 10.1016/j.mrrev.2014.12.002. Epub 2014 Dec 16.
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Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.从复制蛋白A的研究看DNA加工机器中动态中心蛋白的特征与概念
Prog Biophys Mol Biol. 2015 Mar;117(2-3):206-211. doi: 10.1016/j.pbiomolbio.2014.12.001. Epub 2014 Dec 25.
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A novel mutation in the XPA gene results in two truncated protein variants and leads to a severe XP/neurological symptoms phenotype.XPA基因中的一种新突变导致两种截短的蛋白质变体，并导致严重的着色性干皮病/神经症状表型。
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A new structural insight into XPA-DNA interactions.对XPA与DNA相互作用的新结构见解。
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