Assa Farnaz, Jafarizadeh-Malmiri Hoda, Ajamein Hossein, Vaghari Hamideh, Anarjan Navideh, Ahmadi Omid, Berenjian Aydin
a Faculty of Chemical Engineering , Sahand University of Technology , Tabriz , Iran.
b Department of Chemical Engineering , Ilkhchi Branch, Islamic Azad University , Ilkhchi , Iran.
Crit Rev Biotechnol. 2017 Jun;37(4):492-509. doi: 10.1080/07388551.2016.1185389. Epub 2016 Jun 1.
The potential of magnetic nanoparticles (MNPs) in drug delivery systems (DDSs) is mainly related to its magnetic core and surface coating. These coatings can eliminate or minimize their aggregation under physiological conditions. Also, they can provide functional groups for bioconjugation to anticancer drugs and/or targeted ligands. Chitosan, as a derivative of chitin, is an attractive natural biopolymer from renewable resources with the presence of reactive amino and hydroxyl functional groups in its structure. Chitosan nanoparticles (NPs), due to their huge surface to volume ratio as compared to the chitosan in its bulk form, have outstanding physico-chemical, antimicrobial and biological properties. These unique properties make chitosan NPs a promising biopolymer for the application of DDSs. In this review, the current state and challenges for the application magnetic chitosan NPs in drug delivery systems were investigated. The present review also revisits the limitations and commercial impediments to provide insight for future works.
磁性纳米颗粒（MNPs）在药物递送系统（DDSs）中的潜力主要与其磁芯和表面涂层有关。这些涂层可以消除或最小化其在生理条件下的聚集。此外，它们可以为与抗癌药物和/或靶向配体的生物共轭提供官能团。壳聚糖作为几丁质的衍生物，是一种具有吸引力的天然生物聚合物，来源于可再生资源，其结构中存在反应性氨基和羟基官能团。与块状壳聚糖相比，壳聚糖纳米颗粒（NPs）具有巨大的表面积与体积比，具有出色的物理化学、抗菌和生物学特性。这些独特的性质使壳聚糖纳米颗粒成为用于药物递送系统应用的有前途的生物聚合物。在这篇综述中，研究了磁性壳聚糖纳米颗粒在药物递送系统中应用的现状和挑战。本综述还重新审视了局限性和商业障碍，以为未来的工作提供见解。
