Liang Guoqing, Song Yuxuan, Wang Xiao, Li Jianhui, Shi Huijuan, Zhu Qianxi, Zheng Junbiao, Yu Xiaohua, Li Zheng, Zhang Shucheng, Wang Zengguang, Liu Xiaoqiang
Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai 200032, China.
Sex Health. 2021 May;18(2):156-161. doi: 10.1071/SH20201.
Background To investigate whether serum levels of sex hormone-binding globulin (SHBG) and testosterone are associated with symptomatic late-onset hypogonadism (SLOH) in middle-aged and elderly rural Chinese males.
A population-based cross-sectional study was conducted in Zhejiang rural communities. A total of 965 men (aged 40-80 years) were admitted to the aging males' symptoms (AMS) scale and related physical examinations including body mass index (BMI) and waist circumference were conducted. Serum total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG) and serum lipid levels were measured separately. Serum level of bioavailable testosterone (Bio-T) was calculated.
A total of 965 participants were divided into two groups, symptomatic late-onset hypogonadism (SLOH) group (n = 202) (AMS score ≥27) and control group (n = 763), according to total AMS score. Men in the SLOH group were older (61.57±9.06 vs 54.95±8.27 years) and had a smaller waist circumference (81.06±6.89 vs 82.54±6.60 cm) than those in the control group. Moreover, a relatively higher level of SHBG and lower levels of FT, Bio-T, triglyceride (TG) and total cholesterol (T-CHOL) were found in the SLOH group compared with that in the control group (P < 0.05). Receiver operating characteristic curves (ROC) analysis showed that age (AUC = 0.702, P < 0.001) and SHBG (AUC = 0.617, P < 0.001) were potential predictive indicators for SLOH diagnosis, with the best cut-off values of 59 years for age and 44.40 nmol/L for SHBG.
SHBG might be a potential predictor in men with hypogonadism, whereas BMI had no proportionality to the measurement of AMS. Age and SHBG should be used for SLOH diagnosis.
背景 研究中国农村中老年男性血清性激素结合球蛋白（SHBG）和睾酮水平是否与症状性迟发性性腺功能减退（SLOH）相关。
在浙江农村社区进行一项基于人群的横断面研究。共纳入965名年龄在40 - 80岁的男性，采用老年男性症状（AMS）量表进行评估，并进行包括体重指数（BMI）和腰围在内的相关体格检查。分别测定血清总睾酮（TT）、游离睾酮（FT）、性激素结合球蛋白（SHBG）和血脂水平。计算血清生物可利用睾酮（Bio - T）水平。
根据总AMS评分，965名参与者被分为两组，症状性迟发性性腺功能减退（SLOH）组（n = 202）（AMS评分≥27）和对照组（n = 763）。SLOH组男性年龄大于对照组（61.57±9.06岁 vs 54.95±8.27岁），腰围小于对照组（81.06±6.89 cm vs 82.54±6.60 cm）。此外，与对照组相比，SLOH组SHBG水平相对较高，FT、Bio - T（生物可利用睾酮）、甘油三酯（TG）和总胆固醇（T - CHOL）水平较低（P < 0.05）。受试者工作特征曲线（ROC）分析显示，年龄（AUC = 0.702，P < 0.001）和SHBG（AUC = 0.617，P < 0.001）是SLOH诊断的潜在预测指标，年龄的最佳截断值为59岁，SHBG的最佳截断值为44.40 nmol/L。
SHBG可能是性腺功能减退男性的潜在预测指标，而BMI与AMS测量值无相关性。年龄和SHBG应用于SLOH的诊断。
