Meepagala Kumudini M, Estep Alden S, Becnel James J
NPURU, Agricultural Research Service, U.S. Department of Agriculture , P.O. Box 8048, University, Mississippi 38677, United States.
CMAVE, Agricultural Research Service, U.S. Department of Agriculture , MFRU1600-1700 SW 23rd Drive, Gainesville, Florida 32608, United States.
J Agric Food Chem. 2016 Jun 22;64(24):4914-20. doi: 10.1021/acs.jafc.6b01299. Epub 2016 Jun 9.
Mosquitoes play a major role as vectors that transmit parasitic and viral diseases worldwide, especially in tropical and subtropical countries. Mosquito borne diseases not only affect humans but they also affect livestock in many parts of the world. They carry diseases that are lethal to dogs and horses. Dog heartworm disease (Dirofilaria immitis) is a parasitic disease spread through mosquitoes. This disease is not limited to dogs, but it can affect other animals and humans as well. Eastern equine encephalitis (EEE) and West Nile virus (WNV) are also mosquito borne diseases that affect the central nervous system of horses and cause severe complications and death. Emergence of resistance among mosquitoes to current pesticides has increased the importance of the search for alternate compounds that are effective and environmentally benign with diverse modes of actions than those that are commercially available. Aedes aegypti mosquitoes are the primary vector for transmission of Zika viral fever, yellow fever, dengue fever, and chikungunya. Mosquito control is currently the best strategy to prevent mosquito borne diseases. There are numerous approaches for control of potentially dangerous mosquito populations. These approaches include the use of adulticides (insecticides), larvicides, and, to a limited extent, the use of repellents. Our previous studies have shown the mosquito repellent activity of chromenes. In the present study, we demonstrate larvicidal and adulticidal activity of chroman and chromene analogues against a permethrin susceptible laboratory strain as well as activity against a permethrin-resistant strain of Aedes aegypti.
蚊子作为传播寄生虫病和病毒病的媒介，在全球尤其是热带和亚热带国家发挥着主要作用。蚊媒疾病不仅影响人类，在世界许多地区还影响家畜。它们携带对狗和马致命的疾病。犬心丝虫病（犬恶丝虫）是一种通过蚊子传播的寄生虫病。这种疾病不仅限于狗，也会影响其他动物和人类。东部马脑炎（EEE）和西尼罗河病毒（WNV）也是影响马中枢神经系统并导致严重并发症和死亡的蚊媒疾病。蚊子对现有杀虫剂产生抗药性，这使得寻找比市售产品更有效、对环境友好且具有多种作用方式的替代化合物变得更加重要。埃及伊蚊是传播寨卡病毒热、黄热病、登革热和基孔肯雅热的主要媒介。目前，控制蚊子是预防蚊媒疾病的最佳策略。控制潜在危险蚊子种群有多种方法。这些方法包括使用杀虫剂（杀成虫剂）、杀幼虫剂，以及在有限程度上使用驱避剂。我们之前的研究表明了色烯类化合物的驱蚊活性。在本研究中，我们证明了色满和色烯类似物对氯菊酯敏感的实验室品系的杀幼虫和杀成虫活性，以及对埃及伊蚊氯菊酯抗性品系的活性。
