Keller L S, White W J, Snider M T, Lang C M
Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Lab Anim Sci. 1989 May;39(3):237-42.
Although temperature and relative humidity have been quantitated and their effects on research data studied, few studies have measured the air turnover rates at cage level. We evaluated the air distribution and air turnover rates in unoccupied shoe-box mouse cages, filter-top covered cages and shoe-box mouse cages housed in a flexible film isolator by using discontinuous gas chromatography/mass spectrometry and smoke. Results showed that air turnover was most rapid in the unoccupied shoe-box mouse cage and slowest in the filter-top covered cage. Placing mice in the filter-top covered cage did not significantly improve the air turnover rate. Although filter-top covered cages reduce cage-to-cage transmission of disease, the poor airflow observed within these cages could lead to a buildup of gaseous pollutants that may adversely affect the animal's health.
尽管温度和相对湿度已经被量化，并且它们对研究数据的影响也已得到研究，但很少有研究测量过笼内的空气交换率。我们通过使用间断式气相色谱/质谱联用仪和烟雾，评估了空的鞋盒式小鼠笼、带滤器顶盖的笼子以及置于柔性薄膜隔离器中的鞋盒式小鼠笼内的空气分布和空气交换率。结果显示，空的鞋盒式小鼠笼内的空气交换最快，而带滤器顶盖的笼子内的空气交换最慢。在带滤器顶盖的笼子中放置小鼠并没有显著提高空气交换率。尽管带滤器顶盖的笼子减少了笼间疾病传播，但在这些笼子内观察到的不良气流可能会导致气态污染物的积聚，这可能会对动物健康产生不利影响。
