癌症当前免疫疗法的基本概述

Basic Overview of Current Immunotherapy Approaches in Cancer.

作者信息

Velcheti Vamsidhar, Schalper Kurt

机构信息

From the Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; Departments of Pathology and Medicine (Medical Oncology), Yale School of Medicine, New Haven, CT.

出版信息

Am Soc Clin Oncol Educ Book. 2016;35:298-308. doi: 10.1200/EDBK_156572.

DOI:10.1200/EDBK_156572

PMID:27249709

Abstract

Recent success of immunotherapy strategies such as immune checkpoint blockade in several malignancies has established the role of immunotherapy in the treatment of cancer. Cancers use multiple mechanisms to co-opt the host-tumor immune interactions, leading to immune evasion. Our understanding of the host-tumor interactions has evolved over the past few years and led to various promising new therapeutic strategies. This article will focus on the basic principles of immunotherapy, novel pathways/agents, and combinatorial immunotherapies.

摘要

免疫检查点阻断等免疫治疗策略近期在多种恶性肿瘤中取得的成功，确立了免疫治疗在癌症治疗中的作用。癌症利用多种机制来操控宿主与肿瘤的免疫相互作用，从而实现免疫逃逸。在过去几年里，我们对宿主与肿瘤相互作用的理解不断发展，并催生了各种有前景的新治疗策略。本文将聚焦于免疫治疗的基本原理、新途径/药物以及联合免疫疗法。